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Literature summary for 2.1.1.355 extracted from

  • Smolko, A.E.; Shapiro-Kulnane, L.; Salz, H.K.
    The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells (2018), Nat. Commun., 9, 4155 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Drosophila melanogaster overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
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Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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Drosophila melanogaster Q32KD2
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Source Tissue

Source Tissue Comment Organism Textmining
germ cell
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 Drosophila melanogaster
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 overall reaction Drosophila melanogaster 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
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 ?

Synonyms

Synonyms Comment Organism
H3K9 methyltransferase
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 Drosophila melanogaster
SETDB1
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 Drosophila melanogaster

General Information

General Information Comment Organism
malfunction enzyme loss blocks germ cell differentiation Drosophila melanogaster
physiological function female identity is secured by an H3K9me3 epigenetic pathway in which Sxl is the upstream female-specific regulator, SETDB1 is the required chromatin writer, and phf7 is one of the critical SETDB1 target genes. Germ cell specific loss of the H3K9me3 pathway members, the H3K9 methyltransferase SETDB1, WDE, and HP1a, leads to ectopic expression of genes, many of which are normally expressed in testis. SETDB1 controls the accumulation of H3K9me3 over a subset of these genes without spreading into neighboring loci Drosophila melanogaster