Literature summary for 2.1.1.355 extracted from

Chiba, T.; Saito, T.; Yuki, K.; Zen, Y.; Koide, S.; Kanogawa, N.; Motoyama, T.; Ogasawara, S.; Suzuki, E.; Ooka, Y.; Tawada, A.; Otsuka, M.; Miyazaki, M.; Iwama, A.; Yokosuka, O.
Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma (2015), Int. J. Cancer, 136, 289-298.

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Application

Application	Comment	Organism
medicine	hepatocellular tumor tissues show high levels of H3K9me3 and H3K9-specific methyltransferase ESET proteins in 23 (54.8%) and 29 (69.0%) of 42 samples, respectively. Expression levels of isoform SUV39H1 but not those of ESET are significantly correlated with H3K9me3 levels. The cumulative HCC recurrence rate is significantly higher for patients with elevated SUV39H1 expression and H3K9me3 levels	Homo sapiens
medicine	SUV39H1 knockdown reduces H3K9me3 levels and impairs HCC cell growth and sphere formation. The pharmacological inhibition of SUV39H1 by chaetocin results in cell growth inhibition and inducing cellular apoptosis in culture and xenograft subcutaneous tumors. 24 of 42 HCC surgical samples display high levels of SUV39H1 expression compared with corresponding nontumor tissues. Tumor tissues show high levels of H3K9me3 and H3K9-specific methyltransferase ESET proteins in 23 (54.8%) and 29 (69.0%) samples, respectively. Expression levels of SUV39H1 but not those of ESET are significantly correlated with H3K9me3 levels. The cumulative HCC recurrence rate is significantly higher for patients with elevated SUV39H1 expression and H3K9me3 levels	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O43463	-	-
Homo sapiens	Q15047	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HuH-1 cell	-	Homo sapiens	-
HuH-6 cell	-	Homo sapiens	-
Huh-7 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
ESET	-	Homo sapiens
SETDB1	-	Homo sapiens
SUV39H1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	SUV39H1 knockdown reduces H3K9me3 levels and impairs HCC cell growth and sphere formation. The pharmacological inhibition of SUV39H1 by chaetocin results in cell growth inhibition and inducing cellular apoptosis in culture and xenograft subcutaneous tumors. 24 of 42 HCC surgical samples display high levels of SUV39H1 expression compared with corresponding nontumor tissues. Tumor tissues show high levels of H3K9me3 and H3K9-specific methyltransferase ESET proteins in 23 (54.8%) and 29 (69.0%) samples, respectively. Expression levels of SUV39H1 but not those of ESET are significantly correlated with H3K9me3 levels	Homo sapiens

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Release 2023.1 (January 2023)