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Literature summary for 2.1.1.355 extracted from

  • Veiseth, S.V.; Rahman, M.A.; Yap, K.L.; Fischer, A.; Egge-Jacobsen, W.; Reuter, G.; Zhou, M.M.; Aalen, R.B.; Thorstensen, T.
    The SUVR4 histone lysine methyltransferase binds ubiquitin and converts H3K9me1 to H3K9me3 on transposon chromatin in Arabidopsis (2011), PLoS Genet., 7, e1001325.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.355

Inhibitors

Inhibitors Comment Organism Structure
additional information SUVR4 enzyme activity is not affected by monomethylated histone H3(K4) Arabidopsis thaliana
trimethylated histone H3(K4)
-
 Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus the enzyme localizes at euchromatin and heterochromatin Arabidopsis thaliana 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Arabidopsis thaliana no activity is observed on trimethylated histone H3(K9) peptides either with or without ubiquitin ?
-
 ?
S-adenosyl-L-methionine + dimethylated histone H3(K9) Arabidopsis thaliana the activity on dimethylated histone H3(K9) peptides is several folds lower than when monomethylated histone H3(K9) peptides are used S-adenosyl-L-homocysteine + trimethylated histone H3(K9)
-
 ?
S-adenosyl-L-methionine + monomethylated histone H3(K9) Arabidopsis thaliana the SUVR4 product specificity shifts from di- to trimethylation in the presence of free ubiquitin. SUVR4 in vivo specifically converts monomethylated histone H3(K9) to trimethylated histone H3(K9) at transposons and pseudogenes S-adenosyl-L-homocysteine + trimethylated histone H3(K9)
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no activity is observed on trimethylated histone H3(K9) peptides either with or without ubiquitin Arabidopsis thaliana ?
-
 ?
S-adenosyl-L-methionine + dimethylated histone H3(K9) the activity on dimethylated histone H3(K9) peptides is several folds lower than when monomethylated histone H3(K9) peptides are used Arabidopsis thaliana S-adenosyl-L-homocysteine + trimethylated histone H3(K9)
-
 ?
S-adenosyl-L-methionine + monomethylated histone H3(K9) the SUVR4 product specificity shifts from di- to trimethylation in the presence of free ubiquitin. SUVR4 in vivo specifically converts monomethylated histone H3(K9) to trimethylated histone H3(K9) at transposons and pseudogenes Arabidopsis thaliana S-adenosyl-L-homocysteine + trimethylated histone H3(K9)
-
 ?

Synonyms

Synonyms Comment Organism
histone H3K9 trimethylase
-
 Arabidopsis thaliana
histone lysine methyltransferase
-
 Arabidopsis thaliana
HKMTase
-
 Arabidopsis thaliana
SUVR4
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
physiological function SUVR4 is involved in the epigenetic defense mechanism by trimethylating histone H3(K9) to suppress potentially harmful transposon activity Arabidopsis thaliana