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Literature summary for 2.1.1.355 extracted from

  • Gupta-Agarwal, S.; Franklin, A.V.; Deramus, T.; Wheelock, M.; Davis, R.L.; McMahon, L.L.; Lubin, F.D.
    G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation (2012), J. Neurosci., 32, 5440-5453.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.355

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
entorhinal cortex
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 Rattus norvegicus
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hippocampus
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + histone H3(K9)
-
 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
G9a
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 Rattus norvegicus
G9a/G9a-like protein lysine dimethyltransferase complex
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 Rattus norvegicus
GLP G9a-like protein Rattus norvegicus
histone H3 lysine 9 methyltransferase
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction inhibition of G9a/GLP in the entorhinal cortex (EC), but not in the hippocampus, enhances contextual fear conditioning relative to control animals. Downregulation of G9a/GLP activity in the EC enhances histone H3(K9) dimethylation in hippocampus area CA1, resulting in transcriptional silencing of the non-memory permissive gene COMT in the hippocampus Rattus norvegicus
physiological function G9a/GLP activity is critical for hippocampus-dependent long-term potentiation initiated in the entorhinal cortex via the perforant pathway, but not the temporoammonic pathway. G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation Rattus norvegicus