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Literature summary for 2.1.1.355 extracted from

  • Dong, K.B.; Maksakova, I.A.; Mohn, F.; Leung, D.; Appanah, R.; Lee, S.; Yang, H.W.; Lam, L.L.; Mager, D.L.; Schuebeler, D.; Tachibana, M.; Shinkai, Y.; Lorincz, M.C.
    DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity (2008), EMBO J., 27, 2691-2701.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.355

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + histone L-lysine
-
 Mus musculus S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
-
 ?

Synonyms

Synonyms Comment Organism
H3K9 histone methyltransferases
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 Mus musculus
histone lysine methyltransferase
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 Mus musculus
HMTase
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 Mus musculus
lysine methyltransferase G9a
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 Mus musculus

General Information

General Information Comment Organism
malfunction embryonic stem cells lacking the H3K9 HMTase G9a show a significant reduction in DNA methylation of retrotransposons, major satellite repeats and densely methylated CpG-rich promoters Mus musculus
physiological function DNA methylation of retrotransposons in embryonic stem cells requires the lysine methyltransferase G9a but not its catalytic activity Mus musculus