Cloned (Comment) | Organism |
---|---|
the 70 kDa full-length form is expressed in HEK-293T cells | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | the full-length of PRDM8 is localized exclusively in the nuclear region | Mus musculus | 5634 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
30000 | - |
the 30 kDa PRDM8 is most abundant in testis, heart, liver, and kidney, SDS-PAGE | Mus musculus |
70000 | - |
the 70 kDa full-length PRDM8 is most abundant in brain and testis, SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | PRDM8 of 70 kDa | Mus musculus | - |
heart | PRDM8 of 30 kDa is expressed most prominently in cardiomyocytes from the heart | Mus musculus | - |
kidney | PRDM8 of 30 kDa | Mus musculus | - |
liver | PRDM8 of 70 kDa and of 30 kDa | Mus musculus | - |
additional information | PRDM8 is not expressed in intestinal smooth muscles | Mus musculus | - |
oral epithelium | - |
Mus musculus | - |
renal tubule | - |
Mus musculus | - |
testis | PRDM8 of 70 kDa | Mus musculus | - |
tongue | PRDM8 is expressed most prominently in striated skeletal muscle from the tongue | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + histone H2A | - |
Mus musculus | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + histone H2B | - |
Mus musculus | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + histone H3(K9) | PRDM8 specifically methylates H3(K9) of histones | Mus musculus | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + histone H4 | - |
Mus musculus | S-adenosyl-L-homocysteine + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
histone methyltransferase | - |
Mus musculus |
HMTase | - |
Mus musculus |
PRDM8 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | the expression of 70 kDa PRDM8 in brain and testis abruptly increases 3 weeks after birth | up |
General Information | Comment | Organism |
---|---|---|
physiological function | PRDM8 repressed the expression of steroidogenic markers, p450c17c and luteinizing hormone receptor, which indicates its regulatory role in mouse testis development and steroidogenesis | Mus musculus |