Activating Compound | Comment | Organism | Structure |
---|---|---|---|
deferoxamine | increases G9a protein and activity in A549 cells, moreover, increases the methyltransferase activity of overexpressed GFP-hG9a fusion proteins | Homo sapiens | |
dimethyloxalylglycine | increases G9a protein and activity in A549 cells | Homo sapiens | |
additional information | hypoxia increases nuclear G9a protein by posttranslational mechanisms and its methyltransferase activity | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | G9a plays an important role in the hypoxia-induced dimethylated histone H3 lysine 9, which inhibits the expression of several genes that likely leads to solid tumor progression | Mus musculus |
medicine | G9a plays an important role in the hypoxia-induced dimethylated histone H3 lysine 9, which inhibits the expression of several genes that likely leads to solid tumor progression | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | in G9a-/- embryonic stem cells, the increase in dimethylated histone H3 lysine 9 is significantly mitigated following hypoxia challenge | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cyclohexamide | decreases nuclear G9a protein but does not prevent its relative increase during hypoxic stress | Homo sapiens | |
additional information | hypoxia does not cause any measurable changes of G9a mRNA at earlier time intervals (1 and 3 hours) but leads to a significant decrease at 6 hours after challenge | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | G9a protein not detected in the cytoplasm | Homo sapiens | - |
- |
nucleus | overexpressed exogenous G9a protein | Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
embryo | embryonic fibroblast cell | Mus musculus | - |
embryonic stem cell | - |
Mus musculus | - |
fibroblast | embryonic fibroblast cell | Mus musculus | - |
HEK-293 cell | - |
Homo sapiens | - |
additional information | MES cell and HIF-1alpha cell | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
histone methyltransferase G9a | - |
Mus musculus |
histone methyltransferase G9a | - |
Homo sapiens |