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Literature summary for 2.1.1.354 extracted from

  • Zhang, Y.; Li, C.; Yang, Z.
    Is MYND domain-mediated assembly of SMYD3 complexes involved in calcium dependent signaling? (2019), Front. Mol. Biosci., 6, 121 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.354

Activating Compound

Activating Compound Comment Organism Structure
heat shock protein 90
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4 Homo sapiens overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine4 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9H7B4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
thyroid gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4 overall reaction Homo sapiens 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine4
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4
-
 ?

Synonyms

Synonyms Comment Organism
histone H3K4 methyltransferase
-
 Homo sapiens
Smyd3
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme is involved in calcium dependent signaling pathways through forming complexes with the phospholipase PLCB3, calcium/calmodulin dependent kinase CAMK2B, or calcineurin inhibitor RCAN3. The enzyme is involved in epigenetic transcriptional regulation Homo sapiens