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Literature summary for 2.1.1.354 extracted from

  • Dhar, S.S.; Zhao, D.; Lin, T.; Gu, B.; Pal, K.; Wu, S.J.; Alam, H.; Lv, J.; Yun, K.; Gopalakrishnan, V.; Flores, E.R.; Northcott, P.A.; Rajaram, V.; Li, W.; Shilatifard, A.; Sillitoe, R.V.; Chen, K.; Lee, M.G.
    MLL4 is required to maintain broad H3K4me3 peaks and super-enhancers at tumor suppressor genes (2018), Mol. Cell, 70, 825-841.e6 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.354

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4 Mus musculus overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine4 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q6PDK2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4 overall reaction Mus musculus 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine4
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4
-
 ?

Synonyms

Synonyms Comment Organism
ALR
-
 Mus musculus
H3K4 methyltransferase
-
 Mus musculus
KMT2D
-
 Mus musculus
MLL2
-
 Mus musculus
MLL4
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme knockout spontaneously induces medulloblastoma. Enzyme loss upregulates oncogenic Ras and Notch pathways while downregulating neuronal gene expression programs. Enzyme loss downregulates tumor suppressor genes (e.g., Dnmt3a and Bcl6). Enzyme loss increases cell proliferation in the cerebellum but negatively impacts cerebellar neurons Mus musculus
metabolism the enzyme indirectly downregulates Ras activators by enhancing DNMT3A-mediated DNA methylation. The enzyme indirectly antagonizes Notch pathway components (e.g., Hes1 and Jag1) by upregulating SIRT1/BCL6-mediated H4K16 deacetylation Mus musculus