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Literature summary for 2.1.1.354 extracted from
- Proper activity of histone H3 lysine 4 (H3K4) methyltransferase is required for morphogenesis during zebrafish cardiogenesis (2015), Mol. Cells, 38, 580-586.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Danio rerio | Q6DHG0 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | high expression within developing heart | Danio rerio | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SetD7 | - |
Danio rerio |
| Smyd3 | - |
Danio rerio |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | knock-down of either histone H3 lysine methyltransferase Smyd3 or SetD7 genes leads to severe defects in cardiac morphogenesis without altering the expression pattern of heart markers, including cmlc2, vmhc, and amhc. Double knock-down of both Smyd3 and SetD7 causes synergistic defects in heart development. Overexpression of these genes also causes the heart morphogenesis defect in zebrafish | Danio rerio |
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Release 2023.1 (January 2023)
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