Literature summary for 2.1.1.354 extracted from

Ardehali, M.B.; Mei, A.; Zobeck, K.L.; Caron, M.; Lis, J.T.; Kusch, T.
Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription (2011), EMBO J., 30, 2817-2828.

Search for more literature for 2.1.1.354

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in S2 cells	Drosophila melanogaster

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
632800	-	x * 632800, all dSet1-complex subunits, calculated from amino acid sequence	Drosophila melanogaster
670000	-	x * 670000, all dSet1-complex subunits, SDS-PAGE	Drosophila melanogaster

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Drosophila melanogaster

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + histone H3(K4)	H3K4 methyltransferase dSet1 is predominantly responsible for histone H3(K4) trimethylation	Drosophila melanogaster	?	-	?

Subunits

Subunits	Comment	Organism
?	x * 632800, all dSet1-complex subunits, calculated from amino acid sequence	Drosophila melanogaster
?	x * 670000, all dSet1-complex subunits, SDS-PAGE	Drosophila melanogaster

Synonyms

Synonyms	Comment	Organism
H3K4 methyltransferase	-	Drosophila melanogaster
histone H3 lysine 4 trimethyltransferase	-	Drosophila melanogaster
SET1	-	Drosophila melanogaster

General Information

General Information	Comment	Organism
physiological function	Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription. dSet1-dependent histone H3 lysine 4 trimethylation is responsible for the generation of a chromatin structure at active promoters that ensures optimal polymerase II release into productive elongation	Drosophila melanogaster

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Release 2023.1 (January 2023)