Literature summary for 2.1.1.354 extracted from

Raman, S.B.; Nguyen, M.H.; Zhang, Z.; Cheng, S.; Jia, H.Y.; Weisner, N.; Iczkowski, K.; Clancy, C.J.
Candida albicans SET1 encodes a histone 3 lysine 4 methyltransferase that contributes to the pathogenesis of invasive candidiasis (2006), Mol. Microbiol., 60, 697-709.

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Application

Application	Comment	Organism
medicine	SET1 regulates multiple processes important to the pathogenesis of candidiasis, antibody responses against a unique N-terminal fragment of Candida albicans Set1p distinguish patients with candidiasis from controls without disease, the Set1p N-terminal fragment does not exhibit significant homology to eukaryotic or microbial proteins, and might represent a novel therapeutic, preventive or diagnostic target	Candida albicans

Protein Variants

Protein Variants	Comment	Organism
additional information	HMT activity of set1 null mutant strain is significantly reduced compared with the wild-type strain	Saccharomyces cerevisiae
additional information	set1 null mutant, heterozygous mutant, and reinsertion strains, HMT activity of the set1 null mutant strain is significantly reduced compared with strain CAI12, heterozygous mutant and reinsertion strains, disruption of SET1 results in complete loss of methylation of histone 3 at lysine residue 4, hyperfilamentous growth under embedded conditions, less negative cell surface charges and diminished adherence to epithelial cells, effects reversed upon gene reinsertion at a disrupted locus	Candida albicans

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	-	-
Candida albicans CAI12	-	-	-
Saccharomyces cerevisiae	-	wild-type strain ATCC MYA-2089 and mutant strain ATCC MYA-1924	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant C-terminal SET domain and the unique N-terminal fragment of Set1p	Candida albicans

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + histone H3(K4)	-	Saccharomyces cerevisiae	?	-	?
S-adenosyl-L-methionine + histone H3(K4)	-	Candida albicans	?	-	?
S-adenosyl-L-methionine + histone H3(K4)	-	Candida albicans CAI12	?	-	?

Synonyms

Synonyms	Comment	Organism
histone 3 lysine 4 methyltransferase	-	Saccharomyces cerevisiae
histone 3 lysine 4 methyltransferase	-	Candida albicans
HMT	-	Saccharomyces cerevisiae
HMT	-	Candida albicans
Set1p	-	Saccharomyces cerevisiae
Set1p	-	Candida albicans

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Release 2023.1 (January 2023)