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Literature summary for 2.1.1.352 extracted from

  • Park, M.; Chen, X.; Lang, D.; Ng, K.; Facchini, P.
    Heterodimeric O-methyltransferases involved in the biosynthesis of noscapine in opium poppy (2018), Plant J., 95, 252-267 .
    View publication on PubMed
Search for more literature for 2.1.1.352

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Papaver somniferum

Protein Variants

Protein Variants Comment Organism
S122Y profound negative effects on dimerization and activity Papaver somniferum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine Papaver somniferum this activity is part of the noscapine biosynthesis pathway S-adenosyl-L-homocysteine + 3-O-acetylpapaveroxine
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Organism

Organism UniProt Comment Textmining
Papaver somniferum I3PLQ6 I3PLQ6: 4'-O-desmethyl-3-O-acetylpapaveroxine O-methyltransferase subunit MT2, I3PLQ7: 4'-O-desmethyl-3-O-acetylpapaveroxine O-methyltransferase subunit MT3
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine this activity is part of the noscapine biosynthesis pathway Papaver somniferum S-adenosyl-L-homocysteine + 3-O-acetylpapaveroxine
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 ?
S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine 3-O-acetyl-4'-O-demethylpapaveroxine i.e. 6-[(S)-acetoxy[(5R)-4-hydroxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]methyl]-2,3-dimethoxybenzaldehyde. 3-O-Acetylpapaveroxine i.e. 6-[(S)-acetoxy[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]methyl]-2,3-dimethoxybenzaldehyde Papaver somniferum S-adenosyl-L-homocysteine + 3-O-acetylpapaveroxine
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 ?

Subunits

Subunits Comment Organism
heterodimer complex of the OMT2 gene product and the product of either OMT3 or 6OMT. OMT2 is the catalytic subunit in both complexes. 6OMT shares 81% amino acid sequence identity with OMT3 Papaver somniferum

General Information

General Information Comment Organism
metabolism this activity is part of the noscapine biosynthesis pathway Papaver somniferum