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Literature summary for 2.1.1.348 extracted from

  • Hao, H.; Hao, S.; Chen, H.; Chen, Z.; Zhang, Y.; Wang, J.; Wang, H.; Zhang, B.; Qiu, J.; Deng, F.; Guan, W.
    N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication (2019), Nucleic Acids Res., 47, 362-374 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.348

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Chlorocebus sabaeus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + adenine in RNA Chlorocebus sabaeus
-
 S-adenosyl-L-homocysteine + N6-methyladenine in RNA
-
 ?

Organism

Organism UniProt Comment Textmining
Chlorocebus aethiops
-
-
-
Chlorocebus sabaeus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Vero cell
-
 Chlorocebus aethiops
-
Vero cell
-
 Chlorocebus sabaeus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + adenine in RNA
-
 Chlorocebus sabaeus S-adenosyl-L-homocysteine + N6-methyladenine in RNA
-
 ?

Synonyms

Synonyms Comment Organism
m6A methyltransferase
-
 Chlorocebus sabaeus
METTL3
-
 Chlorocebus aethiops
METTL3
-
 Chlorocebus sabaeus

General Information

General Information Comment Organism
drug target m6A modification may be a target for antivirals of enterovirus 71 (EV71) Chlorocebus aethiops
malfunction enzyme knockdown results in decreased enterovirus 71 replication Chlorocebus sabaeus
physiological function the enzyme (METTL3) interacts with viral RNA-dependent RNA polymerase 3D and induces enhanced sumoylation and ubiquitination of the 3D polymerase that boosts viral replication. The host m6A modification complex interacts with viral proteins to modulate enterovirus 71 (EV71) replication Chlorocebus aethiops
physiological function the enzyme interacts with viral RNA-dependent RNA polymerase 3D and induces enhanced sumoylation and ubiquitination of the 3D polymerase that boosts viral replication Chlorocebus sabaeus