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Literature summary for 2.1.1.348 extracted from

  • Alarcon, C.R.; Lee, H.; Goodarzi, H.; Halberg, N.; Tavazoie, S.F.
    N6-methyladenosine marks primary microRNAs for processing. (2015), Nature, 519, 482-485 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.348

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + adenine in RNA Homo sapiens
-
 S-adenosyl-L-homocysteine + N6-methyladenine in RNA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86U44
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + adenine in RNA
-
 Homo sapiens S-adenosyl-L-homocysteine + N6-methyladenine in RNA
-
 ?

Synonyms

Synonyms Comment Organism
methyltransferase like 3
-
 Homo sapiens
METTL3 catalytic subunit of a multi-component enzyme Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme depletion reduces the binding of DGCR8 to pri-miRNAs and results in the global reduction of mature miRNAs and concomitant accumulation of unprocessed pri-miRNAs Homo sapiens
metabolism the enzyme methylates pri-miRNAs, marking them for recognition and processing by the RNA binding protein DGCR8. The enzyme is required for basal expression of the vast majority of miRNAs in these cancerous and non-cancerous cells Homo sapiens