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Literature summary for 2.1.1.348 extracted from

  • Liu, J.; Yue, Y.; He, C.
    Preparation of human nuclear RNA m6A methyltransferases and demethylases and biochemical characterization of their catalytic activity (2015), Methods Enzymol., 560, 117-130 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 insect cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + adenine in RNA Homo sapiens
-
S-adenosyl-L-homocysteine + N6-methyladenine in RNA
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86U44
-
-
Homo sapiens Q9HCE5
-
-

Purification (Commentary)

Purification (Comment) Organism
anti-Flag M2 affinity gel chromatography and Superdex S200 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme preferentially methylates substrates containing the consensus sequence Pu[G>A]m6AC[U>A>C], but exhibit no obvious preference to the stem-loop structure for N6-methyladenine deposition Homo sapiens ?
-
-
S-adenosyl-L-methionine + adenine in RNA
-
Homo sapiens S-adenosyl-L-homocysteine + N6-methyladenine in RNA
-
?

Subunits

Subunits Comment Organism
? x * about 70000, SDS-PAGE Homo sapiens
? x * about 65000, METTL14, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
METTL14
-
Homo sapiens
METTL3
-
Homo sapiens
RNA m6A methyltransferase
-
Homo sapiens