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Literature summary for 2.1.1.348 extracted from

  • Chen, M.; Wie, L.; Law, C.T.; Tsang, F.H.; Shen, J.; Cheng, C.L.; Tsang, L.H.; Ho, D.W.; Chiu, D.K.; Lee, J.M.; Wong, C.C.; Ng, I.O.; Wong, C.M.
    RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2 (2018), Hepatology, 67, 2254-2270 .
    View publication on PubMed

Application

Application Comment Organism
medicine enzyme overexpression is associated with poor prognosis of patients with hepatocellular carcinoma Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + adenine in mRNA Homo sapiens
-
S-adenosyl-L-homocysteine + N6-methyladenine in mRNA
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-
Huh-7 cell
-
Homo sapiens
-
MHCC97-L cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + adenine in mRNA
-
Homo sapiens S-adenosyl-L-homocysteine + N6-methyladenine in mRNA
-
?

Synonyms

Synonyms Comment Organism
METTL3
-
Homo sapiens
RNA N6-methyladenosine methyltransferase-like 3
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is significantly up-regulated in human hepatocellular carcinoma and multiple solid tumors up

General Information

General Information Comment Organism
malfunction enzyme knockdown drastically reduces hepatocellular carcinoma cell proliferation, migration, and colony formation in vitro. Enzyme knockout remarkably suppresses hepatocellular carcinoma tumorigenicity and lung metastasis in vivo Homo sapiens
physiological function overexpression of the enzyme significantly promotes hepatocellular carcinoma growth both in vitro and in vivo. The enzyme represses suppressor of cytokine signalling 2 expression in hepatocellular carcinoma through an N6-methyladenosine-reader protein YTHDF2-dependent mechanism Homo sapiens