Application | Comment | Organism |
---|---|---|
medicine | enzyme overexpression is associated with poor prognosis of patients with hepatocellular carcinoma | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + adenine in mRNA | Homo sapiens | - |
S-adenosyl-L-homocysteine + N6-methyladenine in mRNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
Huh-7 cell | - |
Homo sapiens | - |
MHCC97-L cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + adenine in mRNA | - |
Homo sapiens | S-adenosyl-L-homocysteine + N6-methyladenine in mRNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
METTL3 | - |
Homo sapiens |
RNA N6-methyladenosine methyltransferase-like 3 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme is significantly up-regulated in human hepatocellular carcinoma and multiple solid tumors | up |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme knockdown drastically reduces hepatocellular carcinoma cell proliferation, migration, and colony formation in vitro. Enzyme knockout remarkably suppresses hepatocellular carcinoma tumorigenicity and lung metastasis in vivo | Homo sapiens |
physiological function | overexpression of the enzyme significantly promotes hepatocellular carcinoma growth both in vitro and in vivo. The enzyme represses suppressor of cytokine signalling 2 expression in hepatocellular carcinoma through an N6-methyladenosine-reader protein YTHDF2-dependent mechanism | Homo sapiens |