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Literature summary for 2.1.1.346 extracted from

  • Koh, C.w.Q.; Goh, Y.T.; Goh, W.S.S.
    Atlas of quantitative single-base-resolution N6-methyl-adenine methylomes (2019), Nat. Commun., 10, 5636 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + adenine in U6 snRNA Homo sapiens
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 S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86W50
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
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 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + adenine in U6 snRNA
-
 Homo sapiens S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA
-
 ?
S-adenosyl-L-methionine + adenine in U6 snRNA generation of a comprehensive atlas of methylome uniquely mediated by methyltransferase. METTL16 indirectly impacts manifold methylation targets beyond its consensus target motif (UACm6AGAGAA) Homo sapiens S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA
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 ?

Synonyms

Synonyms Comment Organism
METTL16
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 Homo sapiens

General Information

General Information Comment Organism
malfunction METTL16 depletion decreases MAT2A expression, resulting in reduced intracellular S-adenosyl-L-methionine, a key substrate required for RNA methylation. Loss of METTL16 can result in a transcriptome-wide loss of m6A methylation beyond sites directly methylated by METTL16 Homo sapiens