Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 S-adenosyl-L-methionine + protoheme + 2 reduced flavodoxin | Escherichia coli | the gene, and the corresponding protein, is part of a heme uptake and utilization operon that is common to several enteric pathogens | S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + anaerobilin + Fe2+ + 2 oxidized flavodoxin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | A0A384LP51 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 S-adenosyl-L-methionine + protoheme + 2 reduced flavodoxin | the gene, and the corresponding protein, is part of a heme uptake and utilization operon that is common to several enteric pathogens | Escherichia coli | S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + anaerobilin + Fe2+ + 2 oxidized flavodoxin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
chuW | - |
Escherichia coli |
Organism | Comment | Expression |
---|---|---|
Escherichia coli | the enzyme is expressed in the enteric pathogen Escherichia coli O157:H7 when iron is limiting | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the gene, and the corresponding protein, is part of a heme uptake and utilization operon that is common to several enteric pathogens. The physiological role of the gene cluster (ChuW, ChuX, and ChuY) is the liberation of iron during colonization and infection of the intestine. ChuW catalyzes the anaerobic degradation of heme to release iron and produce a reactive tetrapyrrole termed anaerobilin | Escherichia coli |