Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.342 extracted from

  • Mathew, L.; Beattie, N.; Pritchett, C.; Lanzilotta, W.
    New insight into the mechanism of anaerobic heme degradation (2019), Biochemistry, 58, 4641-4654 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 S-adenosyl-L-methionine + protoheme + 2 reduced flavodoxin Escherichia coli the gene, and the corresponding protein, is part of a heme uptake and utilization operon that is common to several enteric pathogens S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + anaerobilin + Fe2+ + 2 oxidized flavodoxin
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli A0A384LP51
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + protoheme + 2 reduced flavodoxin the gene, and the corresponding protein, is part of a heme uptake and utilization operon that is common to several enteric pathogens Escherichia coli S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + anaerobilin + Fe2+ + 2 oxidized flavodoxin
-
?

Synonyms

Synonyms Comment Organism
chuW
-
Escherichia coli

Expression

Organism Comment Expression
Escherichia coli the enzyme is expressed in the enteric pathogen Escherichia coli O157:H7 when iron is limiting up

General Information

General Information Comment Organism
physiological function the gene, and the corresponding protein, is part of a heme uptake and utilization operon that is common to several enteric pathogens. The physiological role of the gene cluster (ChuW, ChuX, and ChuY) is the liberation of iron during colonization and infection of the intestine. ChuW catalyzes the anaerobic degradation of heme to release iron and produce a reactive tetrapyrrole termed anaerobilin Escherichia coli