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Literature summary for 2.1.1.321 extracted from

  • Chen, T.Y.; Lee, S.H.; Dhar, S.S.; Lee, M.G.
    Protein arginine methyltransferase 7-mediated microRNA-221 repression maintains Oct4, Nanog, and Sox2 levels in mouse embryonic stem cells (2018), J. Biol. Chem., 293, 3925-3936 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus Q922X9
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Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell
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 Mus musculus
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Synonyms

Synonyms Comment Organism
PRMT7
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 Mus musculus
protein arginine methyltransferase 7
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 Mus musculus

General Information

General Information Comment Organism
physiological function arginine methyltransferase 7 (PRMT7), an epigenetic modifier, is an essential pluripotency factor that maintains the stemness of mouse embryonic stem cells (ESCs), at least in part, by down-regulating the expression of the anti-stemness microRNA (miRNA) miR-24-2. miR-221 gene-encoded miR-221-3p and miR-221-5p are anti-stemness miRNAs whose expression levels in mouse ESCs are directly repressed by PRMT7. Both miR-221-3p and miR-221-5p target the 3' untranslated regions of mRNA transcripts of the major pluripotency factors Oct4, Nanog, and Sox2 to antagonize mouse ESC stemness. miR-221-5p silences also the expression of its own transcriptional repressor PRMT7. Transfection of miR-221-3p and miR-221-5p mimics induced spontaneous differentiation of mouse ESCs. CRISPR-mediated deletion of the miR-221 gene, as well as specific antisense inhibitors of miR-221-3p and miR-221-5p, inhibit the spontaneous differentiation of PRMT7-depleted mouse ESCs. PRMT7-mediated repression of miR-221-3p and miR-221-5p expression plays a critical role in maintaining mouse ESC stemness Mus musculus