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Literature summary for 2.1.1.321 extracted from

  • Feng, Y.; Maity, R.; Whitelegge, J.P.; Hadjikyriacou, A.; Li, Z.; Zurita-Lopez, C.; Al-Hadid, Q.; Clark, A.T.; Bedford, M.T.; Masson, J.Y.; Clarke, S.G.
    Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions (2013), J. Biol. Chem., 288, 37010-37025.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.321

Cloned(Commentary)

Cloned (Comment) Organism
expression in insect cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information mutation of motif I residues LDIG to AAAA creates a catalytically inactive enzyme that cannot bind AdoMet Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0069
-
 [histone H2B peptide 23-37]-L-arginine pH 7.5, 22°C Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
 x * 80000, SDS-PAGE, x * 81200, calculated Mus musculus
81200
-
 x * 80000, SDS-PAGE, x * 81200, calculated Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q922X9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + [histone H2B peptide 23-37]-L-arginine
-
 Mus musculus S-adenosyl-L-homocysteine + [histone H2B peptide 23-37]-Nomega-methyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [histone H4 peptide 1-20]-L-arginine
-
 Mus musculus S-adenosyl-L-homocysteine + [histone H4 peptide 1-20]-Nomega-methyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [histone H4 peptide 14-22]-L-arginine
-
 Mus musculus S-adenosyl-L-homocysteine + [histone H4 peptide 14-22]-Nomega-methyl-L-arginine
-
 ?

Subunits

Subunits Comment Organism
? x * 80000, SDS-PAGE, x * 81200, calculated Mus musculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.01
-
 [histone H2B peptide 23-37]-L-arginine pH 7.5, 22°C Mus musculus

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.5
-
 [histone H2B peptide 23-37]-L-arginine pH 7.5, 22°C Mus musculus