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Literature summary for 2.1.1.320 extracted from

  • Favia, A.; Salvatori, L.; Nanni, S.; Iwamoto-Stohl, L.; Valente, S.; Mai, A.; Scagnoli, F.; Fontanella, R.; Totta, P.; Nasi, S.; Illi, B.
    The protein arginine methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells (2019), Sci. Rep., 9, 15925 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.320

Organism

Organism UniProt Comment Textmining
Homo sapiens O14744
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-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
protein arginine methyltransferase 5
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 Homo sapiens

General Information

General Information Comment Organism
physiological function the protein arginine methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells. Myc associates with both PRMT1 and PRMT5 being differentially dimethylated. Symmetric (S) by PRMT1 dimethylation protects Myc from degradation, while asymmetric (AS) dimethylation by PRMT5 allows Myc proper turnover. We hypothesize S-Myc as typical of aggressive glioblastoma stem cells, as S-Myc/AS-Myc ratio decreases in differentiating, less aggressive, cells Homo sapiens