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Literature summary for 2.1.1.320 extracted from

  • Chatterjee, B.; Ghosh, K.; Suresh, L.; Kanade, S.
    Curcumin ameliorates PRMT5-MEP50 arginine methyltransferase expression by decreasing the Sp1 and NF-YA transcription factors in the A549 and MCF-7 cells (2019), Mol. Cell. Biochem., 455, 73-90 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 S-adenosyl-L-methionine + [histone H3R2]-L-arginine Homo sapiens the enzyme (PRMT5) catalyse the formation of either activating H3R2me2s or repressive H3R8me2s and H4R3me2s marks as a part of epigenetic histone code 2 S-adenosyl-L-homocysteine + [histone H3R2]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?
2 S-adenosyl-L-methionine + [histone H3R8]-L-arginine Homo sapiens the enzyme (PRMT5) catalyse the formation of either activating H3R2me2s or repressive H3R8me2s and H4R3me2s marks as a part of epigenetic histone code 2 S-adenosyl-L-homocysteine + [histone H3R8]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?
2 S-adenosyl-L-methionine + [histone H4R3]-L-arginine Homo sapiens the enzyme (PRMT5) catalyse the formation of either activating H3R2me2s or repressive H3R8me2s and H4R3me2s marks as a part of epigenetic histone code 2 S-adenosyl-L-homocysteine + [histone H4R3]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O14744
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-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
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MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + [histone H3R2]-L-arginine
-
 Homo sapiens 2 S-adenosyl-L-homocysteine + [histone H3R2]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?
2 S-adenosyl-L-methionine + [histone H3R2]-L-arginine the enzyme (PRMT5) catalyse the formation of either activating H3R2me2s or repressive H3R8me2s and H4R3me2s marks as a part of epigenetic histone code Homo sapiens 2 S-adenosyl-L-homocysteine + [histone H3R2]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?
2 S-adenosyl-L-methionine + [histone H3R8]-L-arginine
-
 Homo sapiens 2 S-adenosyl-L-homocysteine + [histone H3R8]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?
2 S-adenosyl-L-methionine + [histone H3R8]-L-arginine the enzyme (PRMT5) catalyse the formation of either activating H3R2me2s or repressive H3R8me2s and H4R3me2s marks as a part of epigenetic histone code Homo sapiens 2 S-adenosyl-L-homocysteine + [histone H3R8]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?
2 S-adenosyl-L-methionine + [histone H4R3]-L-arginine
-
 Homo sapiens 2 S-adenosyl-L-homocysteine + [histone H4R3]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?
2 S-adenosyl-L-methionine + [histone H4R3]-L-arginine the enzyme (PRMT5) catalyse the formation of either activating H3R2me2s or repressive H3R8me2s and H4R3me2s marks as a part of epigenetic histone code Homo sapiens 2 S-adenosyl-L-homocysteine + [histone H4R3]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?

Expression

Organism Comment Expression
Homo sapiens curcumin downregulates the PRMT5 expression. Curcumin-mediated signalling events are responsible for its anti-oncogene action against PRMT5 down

General Information

General Information Comment Organism
physiological function the enzyme (PRMT5) is involved in tumour initiation, progression, invasion, metastasis as well as poor prognosis in cancer. Increased expression of PRMT5-MEP50 is correlated with the growth of cancer cells Homo sapiens