Literature summary for 2.1.1.320 extracted from

Li, M.; An, W.; Xu, L.; Lin, Y.; Su, L.; Liu, X.
The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells (2019), J. Exp. Clin. Cancer Res., 38, 64 .

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Application

Application	Comment	Organism
medicine	PRMT1 and PRMT5 have opposing effects on chemotherapeutic agent-mediated apoptosis in lung cancer cells. The identification of PRMT5 and PRMT1 as CFLARL regulators involved in cellular apoptosis may help in developing new strategies to increase the sensitivity of cancer cells to chemotherapy, which may eventually benefit lung cancer treatments	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O14744	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung cancer cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PRMT5	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	PRMT5 and PRMT1 are involved in the interaction between CFLARL (a CASP8 and FADD-like apoptosis regulator) and the E3 ligase ITCH. The PRMT5 silencing and PRMT1 overexpression enhance the interaction between CFLARL and ITCH, leading to an altered ubiquitination level and, eventually, the degradation of CFLARL	Homo sapiens

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Release 2023.1 (January 2023)