Literature summary for 2.1.1.320 extracted from

Sheng, X.; Wang, Z.
Protein arginine methyltransferase 5 regulates multiple signaling pathways to promote lung cancer cell proliferation (2016), BMC Cancer, 16, 567 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O14744	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
PC-14 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PRMT5	-	Homo sapiens
protein arginine methyltransferase 5	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	WD repeat domain 77 (WDR77), also known as p44 forms a stoichiometric complex with PRMT5. The PRMT5/p44 complex is required for cellular proliferation of lung and prostate epithelial cells during earlier stages of development and is re-activated during prostate and lung tumorigenesis. PRMT5 and p44 regulate expression of a specific set of genes encoding growth and anti-growth factors, including receptor tyrosine kinases and antiproliferative proteins. Genes whose expression is suppressed by PRMT5 and p44 encode anti-growth factors and inhibit cell growth when ectopically expressed. Genes whose expression is enhanced by PRMT5 and p44 encode growth factors and increased cell growth when expressed. Altered expression of target genes is associated with reactivation of PRMT5 and p44 during lung tumorigenesis	Homo sapiens

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Release 2023.1 (January 2023)