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Literature summary for 2.1.1.320 extracted from

  • Gu, Z.; Li, Y.; Lee, P.; Liu, T.; Wan, C.; Wang, Z.
    Protein arginine methyltransferase 5 functions in opposite ways in the cytoplasm and nucleus of prostate cancer cells (2012), PLoS ONE, 7, e44033.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.320

Application

Application Comment Organism
medicine PRMT5 localizes in the nucleus in benign prostate epithelium, whereas it localizes in the cytoplasm in prostate premalignant and cancer tissues Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm isoform PRMT5 and p44/MED50/WD45/WDR77 colocalize in the cytoplasm, and both are required for the growth of prostate cancer cells in an PRMT5 methyltransferase activity-dependent manner Homo sapiens 5737
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additional information presence of three nuclear exclusion signals in the PRMT5 protein Homo sapiens
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nucleus isoform PRMT5 in the nucleus inhibits cell growth in a methyltransferase activity-independent manner Homo sapiens 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens O14744
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Source Tissue

Source Tissue Comment Organism Textmining
prostate cancer cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + [histone H4]-L-arginine
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 Homo sapiens 2 S-adenosyl-L-homocysteine + [histone H4]-Nomega,Nomega'-dimethyl-L-arginine PRMT5 alone methylates both histone H4 and SmD3 proteins while PRMT5 complexed with p44 and pICln methylates SmD3 but not histone H4 ?
2 S-adenosyl-L-methionine + [SmD3 protein]-L-arginine
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 Homo sapiens 2 S-adenosyl-L-homocysteine + [SmD3 protein]-Nomega,Nomega'-dimethyl-L-arginine PRMT5 alone methylates both histone H4 and SmD3 proteins while PRMT5 complexed with p44 and pICln methylates SmD3 but not histone H4 ?
additional information PRMT5 alone methylates both histone H4 and SmD3 proteins while PRMT5 complexed with p44 and pICln methylates SmD3 but not histone H4 Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
PRMT5
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 Homo sapiens