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Literature summary for 2.1.1.320 extracted from
- Prmt5 is a regulator of muscle stem cell expansion in adult mice (2015), Nat. Commun., 6, 7140.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q8CIG8 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| muscle stem cell | skeletal muscle stem cell | Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PRMT5 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | inactivation of isoform Prmt5 in skeletal muscle stem cells of adult mice prevents expansion of skeletal muscle stem cells, abolishes long-term skeletal muscle stem cells maintenance and abrogates skeletal muscle regeneration. Prmt5 is dispensable for proliferation and differentiation of Pax7+ myogenic progenitor cells during mouse embryonic development. Prmt5 controls proliferation of adult skeletal muscle stem cells by direct epigenetic silencing of the cell cycle inhibitor p21 | Mus musculus |
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Release 2023.1 (January 2023)
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