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Literature summary for 2.1.1.319 extracted from

  • Kim, D.I.; Park, M.J.; Choi, J.H.; Kim, I.S.; Han, H.J.; Yoon, K.C.; Park, S.W.; Lee, M.Y.; Oh, K.S.; Park, S.H.
    PRMT1 and PRMT4 regulate oxidative stress-induced retinal pigment epithelial cell damage in SIRT1-dependent and SIRT1-independent manners (2015), Oxid. Med. Cell. Longev., 2015, 617919.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.319

Application

Application Comment Organism
medicine oxidative stress induces apoptosis both via isoform PRMT1 in a SIRT1-dependent manner and via PRMT4 in a SIRT1-independent manner Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86X55 isoform PRMT4
-
Homo sapiens Q99873 isoform PRMT1
-

Source Tissue

Source Tissue Comment Organism Textmining
retinal pigment epithelial cell retinal pigment epithelial cell Homo sapiens
-

Synonyms

Synonyms Comment Organism
CARM1
-
 Homo sapiens
PRMT1
-
 Homo sapiens
PRMT4
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens H2O2 treatment increases isoforms PRMT1 and PRMT4 expression but decreases sirtuin SIRT1 expression. Similar to H2O2 treatment, PRMT1 or PRMT4 overexpression increases retinal pigment epithelial cell damage up

General Information

General Information Comment Organism
physiological function similar to H2O2 treatment, isoforms PRMT1 or PRMT4 overexpression increases retinal pigment epithelial cell damage. The H2O2-induced cell damage is attenuated by PRMT1 or PRMT4 knockdown and sirtuin SIRT1 overexpression Homo sapiens
physiological function similar to H2O2 treatment, isoforms PRMT1 or PRMT4 overexpression increases retinal pigment epithelial cell damage. The H2O2-induced cell damage is attenuated by PRMT1 or PRMT4 knockdown and sirtuin SIRT1 overexpression. SIRT1 expression is regulated by PRMT1 Homo sapiens