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Literature summary for 2.1.1.319 extracted from
- Type I arginine methyltransferases PRMT1 and PRMT-3 act distributively (2009), J. Biol. Chem., 284, 8274-8282.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00003 | - |
[PABPN1 mutant DeltaC33]-L-arginine | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.00007 | - |
[PABPN1 mutant DeltaC27]-L-arginine | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.00018 | - |
[PABPN1 mutant DELTAC8]-L-arginine | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.00037 | - |
[PABPN1 mutant DeltaC20]-L-arginine | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.00061 | - |
FYSGFNS-dimethyl-R8-PRGRVYATSWY | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.00069 | - |
FYSGFNSRP-methyl-R10-GRVYATSWY | pH not specified in the publication, temperature not specified in the publication | Homo sapiens |  |
| 0.0007 | - |
FYSGFNS-dimethyl-R8-PRG-dimethyl-R12-VYATSWY | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.00323 | - |
[PABPN1 mutant DeltaC40]-L-arginine | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.008 | - |
FYSGFNSRP-dimethyl-R10-G-dimethyl-R12-VYATSWY | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.0222 | - |
FYSGFNS-dimethyl-R8-P-dimethyl-R10-GRVYATSWY | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q99873 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 S-adenosyl-L-methionine + [PABPN1 mutant DeltaC20]-L-arginine | - |
Homo sapiens | 2 S-adenosyl-L-homocysteine + [PABPN1 mutant DeltaC0]-Nomega,Nomega'-dimethyl-L-arginine | overall reaction | ? | |
| 2 S-adenosyl-L-methionine + [PABPN1 mutant DeltaC27]-L-arginine | - |
Homo sapiens | 2 S-adenosyl-L-homocysteine + [PABPN1 mutant DeltaC27]-Nomega,Nomega'-dimethyl-L-arginine | overall reaction | ? | |
| 2 S-adenosyl-L-methionine + [PABPN1 mutant DeltaC33]-L-arginine | - |
Homo sapiens | 2 S-adenosyl-L-homocysteine + [PABPN1 mutant DeltaC33]-Nomega,Nomega'-dimethyl-L-arginine | overall reaction | ? | |
| 2 S-adenosyl-L-methionine + [PABPN1 mutant DeltaC40]-L-arginine | - |
Homo sapiens | 2 S-adenosyl-L-homocysteine + [PABPN1 mutant DeltaC40]-Nomega,Nomega'-dimethyl-L-arginine | overall reaction | ? | |
| 2 S-adenosyl-L-methionine + [PABPN1 mutant DELTAC8]-L-arginine | - |
Homo sapiens | 2 S-adenosyl-L-homocysteine + [PABPN1 mutant DELTAC8]-Nomega,Nomega'-dimethyl-L-arginine | overall reaction | ? | |
| 2 S-adenosyl-L-methionine + [PABPN1 protein]-L-arginine | - |
Homo sapiens | 2 S-adenosyl-L-homocysteine + [PABPN1 protein]-Nomega,Nomega'-dimethyl-L-arginine | overall reaction | ? | |
| additional information | the consecutive transfer of two methyl groups to a single arginine side chain by isoform PRMT1 occurs in a distributive manner, i.e. with intermittent release of the monomethylated intermediate. The reaction is distributive even with substrates containing multiple methyl-accepting arginines, including one with 13 such residues. PRMT1 also does not prefer substrates already containing one or more singly or doubly methylated arginine residues, but the efficiency of methylation of one particular protein strongly depends on the number of methyl-accepting arginine residues it contains | Homo sapiens | ? | - |
? | |
| S-adenosyl-L-methionine + FYSGFNS-dimethyl-R8-P-dimethyl-R10-GRVYATSWY | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + FYSGFNS-dimethyl-R8-PRG-dimethyl-R12-VYATSWY | - |
Homo sapiens | S-adenosyl-L-homocysteine + FYSGFNS-dimethyl-R8-P-methyl-R10-G-dimethyl-R12-VYATSWY | - |
? | |
| S-adenosyl-L-methionine + FYSGFNS-dimethyl-R8-PRGRVYATSWY | - |
Homo sapiens | S-adenosyl-L-homocysteine + FYSGFNS-dimethyl-R8-P-methyl-R10-GRVYATSWY | - |
? | |
| S-adenosyl-L-methionine + FYSGFNSRP-dimethyl-R10-G-dimethyl-R12-VYATSWY | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + FYSGFNSRP-methyl-R10-GRVYATSWY | substrate is derived from bovine PABPN1. Methylation by isoform PRMT1 occurs exclusively at Arg10 | Homo sapiens | S-adenosyl-L-homocysteine + FYSGFNSRP-dimethyl-R10-GRVYATSWY | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PRMT1 | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00021 | - |
[PABPN1 mutant DeltaC33]-L-arginine | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.00042 | - |
[PABPN1 mutant DeltaC40]-L-arginine | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.0017 | - |
[PABPN1 mutant DeltaC27]-L-arginine | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.0024 | - |
FYSGFNS-dimethyl-R8-P-dimethyl-R10-GRVYATSWY | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.0027 | - |
FYSGFNSRP-dimethyl-R10-G-dimethyl-R12-VYATSWY | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.0072 | - |
[PABPN1 mutant DeltaC20]-L-arginine | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.012 | - |
FYSGFNSRP-methyl-R10-GRVYATSWY | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.018 | - |
FYSGFNS-dimethyl-R8-PRGRVYATSWY | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.021 | - |
FYSGFNS-dimethyl-R8-PRG-dimethyl-R12-VYATSWY | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.023 | - |
[PABPN1 mutant DELTAC8]-L-arginine | pH not specified in the publication, temperature not specified in the publication | Homo sapiens |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.1 | - |
FYSGFNS-dimethyl-R8-P-dimethyl-R10-GRVYATSWY | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.1 | - |
[PABPN1 mutant DeltaC40]-L-arginine | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.3 | - |
FYSGFNSRP-dimethyl-R10-G-dimethyl-R12-VYATSWY | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 6.7 | - |
[PABPN1 mutant DeltaC33]-L-arginine | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 17.9 | - |
FYSGFNSRP-methyl-R10-GRVYATSWY | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 18.9 | - |
[PABPN1 mutant DeltaC20]-L-arginine | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 26.5 | - |
[PABPN1 mutant DeltaC27]-L-arginine | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 29.5 | - |
FYSGFNS-dimethyl-R8-PRGRVYATSWY | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 30.4 | - |
FYSGFNS-dimethyl-R8-PRG-dimethyl-R12-VYATSWY | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 133.8 | - |
[PABPN1 mutant DELTAC8]-L-arginine | pH not specified in the publication, temperature not specified in the publication | Homo sapiens |
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