BRENDA - Enzyme Database show
show all sequences of 2.1.1.311

A cluster of methylations in the domain IV of 25S rRNA is required for ribosome stability

Gigova, A.; Duggimpudi, S.; Pollex, T.; Schaefer, M.; Kos, M.; RNA 20, 1632-1644 (2014)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA
Saccharomyces cerevisiae
the methylated residues m5C2278 stabilizes the structure of 25S rRNA and consequently the association of ribosomal proteins with the large ribosomal subunit
S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
-
-
?
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA
Saccharomyces cerevisiae ATCC 204508
the methylated residues m5C2278 stabilizes the structure of 25S rRNA and consequently the association of ribosomal proteins with the large ribosomal subunit
S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Saccharomyces cerevisiae
P53972
-
-
Saccharomyces cerevisiae ATCC 204508
P53972
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA
-
730941
Saccharomyces cerevisiae
S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
-
-
-
?
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA
the methylated residues m5C2278 stabilizes the structure of 25S rRNA and consequently the association of ribosomal proteins with the large ribosomal subunit
730941
Saccharomyces cerevisiae
S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
-
-
-
?
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA
-
730941
Saccharomyces cerevisiae ATCC 204508
S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
-
-
-
?
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA
the methylated residues m5C2278 stabilizes the structure of 25S rRNA and consequently the association of ribosomal proteins with the large ribosomal subunit
730941
Saccharomyces cerevisiae ATCC 204508
S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
-
-
-
?
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA
Saccharomyces cerevisiae
the methylated residues m5C2278 stabilizes the structure of 25S rRNA and consequently the association of ribosomal proteins with the large ribosomal subunit
S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
-
-
?
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA
Saccharomyces cerevisiae ATCC 204508
the methylated residues m5C2278 stabilizes the structure of 25S rRNA and consequently the association of ribosomal proteins with the large ribosomal subunit
S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA
-
730941
Saccharomyces cerevisiae
S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
-
-
-
?
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA
the methylated residues m5C2278 stabilizes the structure of 25S rRNA and consequently the association of ribosomal proteins with the large ribosomal subunit
730941
Saccharomyces cerevisiae
S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
-
-
-
?
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA
-
730941
Saccharomyces cerevisiae ATCC 204508
S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
-
-
-
?
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA
the methylated residues m5C2278 stabilizes the structure of 25S rRNA and consequently the association of ribosomal proteins with the large ribosomal subunit
730941
Saccharomyces cerevisiae ATCC 204508
S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
-
-
-
?
General Information
General Information
Commentary
Organism
physiological function
the methylated residues m5C2278 stabilizes the structure of 25S rRNA and consequently the association of ribosomal proteins with the large ribosomal subunit
Saccharomyces cerevisiae
General Information (protein specific)
General Information
Commentary
Organism
physiological function
the methylated residues m5C2278 stabilizes the structure of 25S rRNA and consequently the association of ribosomal proteins with the large ribosomal subunit
Saccharomyces cerevisiae
Other publictions for EC 2.1.1.311
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
730447
Schosserer
Methylation of ribosomal RNA b ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508
Nat. Commun.
6
6158
2015
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730941
Gigova
A cluster of methylations in t ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508
RNA
20
1632-1644
2014
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1
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730499
Sharma
Yeast Nop2 and Rcm1 methylate ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508
Nucleic Acids Res.
41
9062-9076
2013
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