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Literature summary for 2.1.1.311 extracted from

  • Schosserer, M.; Minois, N.; Angerer, T.B.; Amring, M.; Dellago, H.; Harreither, E.; Calle-Perez, A.; Pircher, A.; Gerstl, M.P.; Pfeifenberger, S.; Brandl, C.; Sonntagbauer, M.; Kriegner, A.; Linder, A.; Weinhaeusel, A.; Mohr, T.; Steiger, M.; Mattanovich, D.; Rinnerthaler, M.; Karl, T.; Sharma, S.
    Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan (2015), Nat. Commun., 6, 6158.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA Saccharomyces cerevisiae Rcm1 is necessary and sufficient for the formation of a large C2278-methylated subpopulation of ribosomes, both under normal and oxidative stress conditions S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
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S-adenosyl-L-methionine + cytosine2278 in 25S rRNA Saccharomyces cerevisiae ATCC 204508 Rcm1 is necessary and sufficient for the formation of a large C2278-methylated subpopulation of ribosomes, both under normal and oxidative stress conditions S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P53972
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Saccharomyces cerevisiae ATCC 204508 P53972
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA Rcm1 is necessary and sufficient for the formation of a large C2278-methylated subpopulation of ribosomes, both under normal and oxidative stress conditions Saccharomyces cerevisiae S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
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?
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA the enzyme is specific for cytosine2278 of the 25S ribosomal RNA. The numbering corresponds to the enzyme from the yeast Saccharomyces cerevisiae Saccharomyces cerevisiae S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
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?
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA Rcm1 is necessary and sufficient for the formation of a large C2278-methylated subpopulation of ribosomes, both under normal and oxidative stress conditions Saccharomyces cerevisiae ATCC 204508 S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
-
?
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA the enzyme is specific for cytosine2278 of the 25S ribosomal RNA. The numbering corresponds to the enzyme from the yeast Saccharomyces cerevisiae Saccharomyces cerevisiae ATCC 204508 S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
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?

Synonyms

Synonyms Comment Organism
RCM1
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Saccharomyces cerevisiae

Expression

Organism Comment Expression
Saccharomyces cerevisiae downregulated in chronologically aged yeast cells down

General Information

General Information Comment Organism
malfunction loss of Rcm1 alters the structural conformation of the ribosome in close proximity to C2278, as well as translational fidelity, and favours recruitment of a distinct subset of oxidative stress-responsive mRNAs into polysomes Saccharomyces cerevisiae