Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA | Saccharomyces cerevisiae | Rcm1 is necessary and sufficient for the formation of a large C2278-methylated subpopulation of ribosomes, both under normal and oxidative stress conditions | S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA | - |
? | |
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA | Saccharomyces cerevisiae ATCC 204508 | Rcm1 is necessary and sufficient for the formation of a large C2278-methylated subpopulation of ribosomes, both under normal and oxidative stress conditions | S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | P53972 | - |
- |
Saccharomyces cerevisiae ATCC 204508 | P53972 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA | Rcm1 is necessary and sufficient for the formation of a large C2278-methylated subpopulation of ribosomes, both under normal and oxidative stress conditions | Saccharomyces cerevisiae | S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA | - |
? | |
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA | the enzyme is specific for cytosine2278 of the 25S ribosomal RNA. The numbering corresponds to the enzyme from the yeast Saccharomyces cerevisiae | Saccharomyces cerevisiae | S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA | - |
? | |
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA | Rcm1 is necessary and sufficient for the formation of a large C2278-methylated subpopulation of ribosomes, both under normal and oxidative stress conditions | Saccharomyces cerevisiae ATCC 204508 | S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA | - |
? | |
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA | the enzyme is specific for cytosine2278 of the 25S ribosomal RNA. The numbering corresponds to the enzyme from the yeast Saccharomyces cerevisiae | Saccharomyces cerevisiae ATCC 204508 | S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RCM1 | - |
Saccharomyces cerevisiae |
Organism | Comment | Expression |
---|---|---|
Saccharomyces cerevisiae | downregulated in chronologically aged yeast cells | down |
General Information | Comment | Organism |
---|---|---|
malfunction | loss of Rcm1 alters the structural conformation of the ribosome in close proximity to C2278, as well as translational fidelity, and favours recruitment of a distinct subset of oxidative stress-responsive mRNAs into polysomes | Saccharomyces cerevisiae |