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Literature summary for 2.1.1.310 extracted from

  • Sharma, S.; Yang, J.; Watzinger, P.; Koetter, P.; Entian, K.D.
    Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively (2013), Nucleic Acids Res., 41, 9062-9076.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
C478A the polysome profile from the mutant reveals defect in 60S biogenesis and significant reduction in polysome fractions compared with isogenic wild type Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + cytosine2870 in 25S rRNA Saccharomyces cerevisiae the enzyme is responsible for the methylation at cytosine2870 of the 25S ribosomal RNA S-adenosyl-L-homocysteine + 5-methylcytosine2870 in 25S rRNA
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S-adenosyl-L-methionine + cytosine2870 in 25S rRNA Saccharomyces cerevisiae ATCC 204508 the enzyme is responsible for the methylation at cytosine2870 of the 25S ribosomal RNA S-adenosyl-L-homocysteine + 5-methylcytosine2870 in 25S rRNA
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P40991
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Saccharomyces cerevisiae ATCC 204508 P40991
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + cytosine2870 in 25S rRNA the enzyme is responsible for the methylation at cytosine2870 of the 25S ribosomal RNA Saccharomyces cerevisiae S-adenosyl-L-homocysteine + 5-methylcytosine2870 in 25S rRNA
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?
S-adenosyl-L-methionine + cytosine2870 in 25S rRNA the enzyme is specific for cytosine2870 of the 25S ribosomal RNA Saccharomyces cerevisiae S-adenosyl-L-homocysteine + 5-methylcytosine2870 in 25S rRNA
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?
S-adenosyl-L-methionine + cytosine2870 in 25S rRNA the enzyme is responsible for the methylation at cytosine2870 of the 25S ribosomal RNA Saccharomyces cerevisiae ATCC 204508 S-adenosyl-L-homocysteine + 5-methylcytosine2870 in 25S rRNA
-
?
S-adenosyl-L-methionine + cytosine2870 in 25S rRNA the enzyme is specific for cytosine2870 of the 25S ribosomal RNA Saccharomyces cerevisiae ATCC 204508 S-adenosyl-L-homocysteine + 5-methylcytosine2870 in 25S rRNA
-
?

Synonyms

Synonyms Comment Organism
NOP2
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Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction the loss of m5C2870 affects ribosome synthesis and processing Saccharomyces cerevisiae