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Literature summary for 2.1.1.308 extracted from
- Bioactive natural products with carbon-phosphorus bonds and their biosynthesis (1999), Nat. Prod. Rep., 16, 589-596.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | a mutant of Streptomyces wedmorensis (A16), defective in the biosynthesis of cobalamin produces fosfomycin only in the presence of hydroxocobalamin. Incorporation of [14CH3]methylcobalamin into fosfomycin by the mutant A16 | Streptomyces wedmorensis |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces fradiae | D2SNF5 | - |
- |
| Streptomyces wedmorensis | Q56184 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin | - |
Streptomyces wedmorensis | (S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin | - |
? |  |
| (2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin | incorporation of 18O in the alcohol function of 18O-labeled HEP into the FM molecule but not of 18O2 gas | Streptomyces fradiae | (S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin | - |
? | |
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