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Literature summary for 2.1.1.304 extracted from

  • Tang, M.C.; Fu, C.Y.; Tang, G.L.
    Characterization of SfmD as a heme peroxidase that catalyzes the regioselective hydroxylation of 3-methyltyrosine to 3-hydroxy-5-methyltyrosine in saframycin A biosynthesis (2012), J. Biol. Chem., 287, 5112-5121.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.304

Cloned(Commentary)

Cloned (Comment) Organism
-
 Streptomyces lavendulae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
41800
-
 x * 41800, SDS-PAGE Streptomyces lavendulae
42000
-
 x * 42000, SDS-PAGE Streptomyces lavendulae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + L-tyrosine Streptomyces lavendulae the enzyme is involved in biosynthesis of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine
-
 ?
S-adenosyl-L-methionine + L-tyrosine Streptomyces lavendulae NRRL 11002 the enzyme is involved in biosynthesis of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces lavendulae B0CN31
-
-
Streptomyces lavendulae NRRL 11002 B0CN31
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Streptomyces lavendulae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + L-tyrosine
-
 Streptomyces lavendulae S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine
-
 ?
S-adenosyl-L-methionine + L-tyrosine the enzyme is involved in biosynthesis of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family Streptomyces lavendulae S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine
-
 ?
S-adenosyl-L-methionine + L-tyrosine
-
 Streptomyces lavendulae NRRL 11002 S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine
-
 ?
S-adenosyl-L-methionine + L-tyrosine the enzyme is involved in biosynthesis of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family Streptomyces lavendulae NRRL 11002 S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine
-
 ?

Subunits

Subunits Comment Organism
? x * 42000, SDS-PAGE Streptomyces lavendulae
? x * 41800, SDS-PAGE Streptomyces lavendulae

Synonyms

Synonyms Comment Organism
SacF
-
 Streptomyces lavendulae
SfmM2
-
 Streptomyces lavendulae

General Information

General Information Comment Organism
physiological function the enzyme is involved in biosynthesis of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family Streptomyces lavendulae