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Literature summary for 2.1.1.301 extracted from

  • Zhang, Q.; van der Donk, W.A.
    Catalytic promiscuity of a bacterial alpha-N-methyltransferase (2012), FEBS Lett., 586, 3391-3397.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + N-terminal L-alanine-[cypemycin] Streptomyces sp.
-
S-adenosyl-L-homocysteine + N-terminal N,N-dimethyl-L-alanine-[cypemycin]
-
?
S-adenosyl-L-methionine + N-terminal L-alanine-[cypemycin] Streptomyces sp. OH-4156
-
S-adenosyl-L-homocysteine + N-terminal N,N-dimethyl-L-alanine-[cypemycin]
-
?

Organism

Organism UniProt Comment Textmining
Streptomyces sp.
-
-
-
Streptomyces sp. OH-4156
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + haloduracin
-
Streptomyces sp. ?
-
?
S-adenosyl-L-methionine + haloduracin
-
Streptomyces sp. OH-4156 ?
-
?
S-adenosyl-L-methionine + L-Lys the enzyme can also methylate the epsilon-amino group of L-Lys. Peptides with Lys in the first or second position from the N-terminus (entries 9-10) are not modified by the enzyme, but a peptide with a Lys at the C-terminus (entry 11) is methylated, with both di- and tetra-methylated products detected in the reaction mixture Streptomyces sp. S-adenosyl-L-homocysteine + N6-methyl-L-lysine
-
?
S-adenosyl-L-methionine + L-Lys the enzyme can also methylate the epsilon-amino group of L-Lys. Peptides with Lys in the first or second position from the N-terminus (entries 9-10) are not modified by the enzyme, but a peptide with a Lys at the C-terminus (entry 11) is methylated, with both di- and tetra-methylated products detected in the reaction mixture Streptomyces sp. OH-4156 S-adenosyl-L-homocysteine + N6-methyl-L-lysine
-
?
S-adenosyl-L-methionine + N-terminal L-alanine-[cypemycin]
-
Streptomyces sp. S-adenosyl-L-homocysteine + N-terminal N,N-dimethyl-L-alanine-[cypemycin]
-
?
S-adenosyl-L-methionine + N-terminal L-alanine-[cypemycin]
-
Streptomyces sp. OH-4156 S-adenosyl-L-homocysteine + N-terminal N,N-dimethyl-L-alanine-[cypemycin]
-
?
S-adenosyl-L-methionine + nisin
-
Streptomyces sp. ?
-
?
S-adenosyl-L-methionine + nisin
-
Streptomyces sp. OH-4156 ?
-
?

Synonyms

Synonyms Comment Organism
alpha-N-methyltransferase
-
Streptomyces sp.
CypM
-
Streptomyces sp.

General Information

General Information Comment Organism
metabolism the enzyme is involved in the biosynthesis of the peptide antibiotic cypemycin Streptomyces sp.