Literature summary for 2.1.1.297 extracted from

Heurgue-Hamard, V.; Champ, S.; Engstrom, A.; Ehrenberg, M.; Buckingham, R.H.
The hemK gene in Escherichia coli encodes the N5-glutamine methyltransferase that modifies peptide release factors (2002), EMBO J., 21, 769-778.

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Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0ACC1	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + [peptide chain release factor 1]-L-glutamine	-	Escherichia coli	S-adenosyl-L-homocysteine + [peptide chain release factor 1]-N5-methyl-L-glutamine	-	?
S-adenosyl-L-methionine + [peptide chain release factor 2]-L-glutamine	-	Escherichia coli	S-adenosyl-L-homocysteine + [peptide chain release factor 2]-N5-methyl-L-glutamine	-	?

Synonyms

Synonyms	Comment	Organism
HemK	-	Escherichia coli

General Information

General Information	Comment	Organism
physiological function	deletion of peptide release factor N5-glutamine methylase leads to very poor growth on rich media and abolishes methylation of release factor RF1. Fast growing spontaneous revertants of the deletion strain contain the mutation T246A or T246S in release factor RF2	Escherichia coli

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Release 2023.1 (January 2023)