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Literature summary for 2.1.1.286 extracted from
- Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in Saccharomyces cerevisiae (2013), Nucleic Acids Res., 41, 5428-5443.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| the gene is identified by screening of all deletion mutants of putative RNA methyltransferase and is confirmed by gene complementation and phenotypic characterization | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleolus | - |
Saccharomyces cerevisiae | 5730 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + adenine2142 in 25S rRNA | Saccharomyces cerevisiae | this methylation is important for resistance towards hydrogen peroxide and the antibiotic anisomycin | S-adenosyl-L-homocysteine + N1-methyladenine2142 in 25S rRNA | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + adenine2142 in 25S rRNA | - |
Saccharomyces cerevisiae | S-adenosyl-L-homocysteine + N1-methyladenine2142 in 25S rRNA | - |
? | |
| S-adenosyl-L-methionine + adenine2142 in 25S rRNA | this methylation is important for resistance towards hydrogen peroxide and the antibiotic anisomycin | Saccharomyces cerevisiae | S-adenosyl-L-homocysteine + N1-methyladenine2142 in 25S rRNA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 25S rRNA m1A2142 methyltransferase | - |
Saccharomyces cerevisiae |
| BMT2 | - |
Saccharomyces cerevisiae |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | this methylation is important for resistance towards hydrogen peroxide and the antibiotic anisomycin | Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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