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Literature summary for 2.1.1.28 extracted from

  • Bao, X.; Lu, C.M.; Liu, F.; Gu, Y.; Dalton, N.D.; Zhu, B.Q.; Foster, E.; Chen, J.; Karliner, J.S.; Ross, J.; Simpson, P.C.; Ziegler, M.G.
    Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine N-methyltransferase knockout mouse (2007), Circulation, 116, 1024-1031.
    View publication on PubMed
Search for more literature for 2.1.1.28

Protein Variants

Protein Variants Comment Organism
additional information construction of enzyme knockout mutant mice, that show resting cardiovascular function, including blood pressure, heart rate, and cardiac output similar to that in wild-type mice, and the basal norepinephrine plasma level is unaltered. However, inhibition of sympathetic innervation with the ganglion blocker hexamethonium causes a 54% smaller decrease in blood pressure in KO mice compared to wild-type mice, and treadmill exercise causes an 11% higher increase in blood pressure, both suggesting impaired vasodilation in KO mice, the enzyme knockout does not change the heart rate response to ganglionic blockade and exercise. KO mice have an increased ratio of left ventricular posterior wall thickness to internal dimensions but do not have cardiac hypertrophy, in restrained, awake KO mice, heart rate and ejection fraction remain unaltered, but cardiac output is significantly reduced because of diminished end-diastolic volume, phenotype, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Mus musculus
-
-
intracellular
-
 Mus musculus 5622
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + norepinephrine Mus musculus epinephrine is an important neurotransmitter and hormone, and epinephrine is required for normal blood pressure and cardiac filling responses to stress, but is not required for tachycardia during stress or normal cardiovascular function at rest S-adenosyl-L-homocysteine + epinephrine
-
 ?
S-adenosyl-L-methionine + norepinephrine Mus musculus C57BL/6 epinephrine is an important neurotransmitter and hormone, and epinephrine is required for normal blood pressure and cardiac filling responses to stress, but is not required for tachycardia during stress or normal cardiovascular function at rest S-adenosyl-L-homocysteine + epinephrine
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
 Mus musculus
-
heart
-
 Mus musculus
-
additional information activity tissue distribution, overview Mus musculus
-
plasma
-
 Mus musculus
-
urine
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 activity tissue distribution, overview Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + norepinephrine
-
 Mus musculus S-adenosyl-L-homocysteine + epinephrine
-
 ?
S-adenosyl-L-methionine + norepinephrine epinephrine is an important neurotransmitter and hormone, and epinephrine is required for normal blood pressure and cardiac filling responses to stress, but is not required for tachycardia during stress or normal cardiovascular function at rest Mus musculus S-adenosyl-L-homocysteine + epinephrine
-
 ?
S-adenosyl-L-methionine + norepinephrine
-
 Mus musculus C57BL/6 S-adenosyl-L-homocysteine + epinephrine
-
 ?
S-adenosyl-L-methionine + norepinephrine epinephrine is an important neurotransmitter and hormone, and epinephrine is required for normal blood pressure and cardiac filling responses to stress, but is not required for tachycardia during stress or normal cardiovascular function at rest Mus musculus C57BL/6 S-adenosyl-L-homocysteine + epinephrine
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Mus musculus