Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LY134046 | selective inhibitor, IC50: 0.0019 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
9-methylnorharman + S-adenosyl-L-methionine | Homo sapiens | PNMT catalyzes the 2N-methylation of beta-carbolines, forming 2N-methylated beta-carbolinium cations, which are structural and functional analogs of the Parkinsonian-inducing toxin MPP+ | ? + S-adenosyl-L-homocysteine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal medulla | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
9-methylnorharman + S-adenosyl-L-methionine | 2N-methylation | Homo sapiens | ? + S-adenosyl-L-homocysteine | - |
? | |
9-methylnorharman + S-adenosyl-L-methionine | PNMT catalyzes the 2N-methylation of beta-carbolines, forming 2N-methylated beta-carbolinium cations, which are structural and functional analogs of the Parkinsonian-inducing toxin MPP+ | Homo sapiens | ? + S-adenosyl-L-homocysteine | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0019 | - |
selective inhibitor, IC50: 0.0019 mM | Homo sapiens | LY134046 |