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Literature summary for 2.1.1.28 extracted from
- The interaction of rabbit adrenal norepinephrine N-methyl transferase isozymes with substrates (1978), Arch. Biochem. Biophys., 185, 228-238.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| norepinephrine | 4 distinct substrate inhibition patterns: enzyme form E1 is not subject to substrate inhibition, isoenzyme E-2 is inhibited by S-adenosyl-L-methionine and norepinephrine, isoenzyme E-3 and E-4 are inhibited by norepinephrine only, isoenzyme E5 is inhibited only by S-adenosyl-L-methionine | Oryctolagus cuniculus |  |
| S-adenosyl-L-methionine | 4 distinct substrate inhibition patterns: enzyme form E1 is not subject to substrate inhibition, isoenzyme E-2 is inhibited by S-adenosyl-L-methionine and norepinephrine, isoenzyme E-3 and E-4 are inhibited by norepinephrine only, isoenzyme E5 is inhibited only by S-adenosyl-L-methionine | Oryctolagus cuniculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| norepinephrine + S-adenosyl-L-methionine | - |
Oryctolagus cuniculus | epinephrine + S-adenosyl-L-homocysteine | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Oryctolagus cuniculus |
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Release 2023.1 (January 2023)
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