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Literature summary for 2.1.1.270 extracted from

  • Kaimoyo, E.; VanEtten, H.
    Inactivation of pea genes by RNAi supports the involvement of two similar O-methyltransferases in the biosynthesis of (+)-pisatin and of chiral intermediates with a configuration opposite that found in (+)-pisatin (2008), Phytochemistry, 69, 76-87.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
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 Pisum sativum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + (+)-6a-hydroxymaackiain Pisum sativum HMM2 is involved primarily in the biosynthesis of (+)-pisatin S-adenosyl-L-homocysteine + (+)-pisatin
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 ?

Organism

Organism UniProt Comment Textmining
Pisum sativum
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-
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Source Tissue

Source Tissue Comment Organism Textmining
root
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 Pisum sativum
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information in Pisum sativum, there are two highly similar hydroxymaackiain 3-O-methyltransferases HMM, with HMM1 prefering 2,7,4'-trihydroxyisoflavanone as a substrate and HMM2 being the specific O-methyltransferase that methylates (+)-6a-hydroxymaackiain Pisum sativum ?
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 ?
S-adenosyl-L-methionine + (+)-6a-hydroxymaackiain isoform HMM2, 6a-hydroxymaackiain is the preferred substrate Pisum sativum S-adenosyl-L-homocysteine + (+)-pisatin
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 ?
S-adenosyl-L-methionine + (+)-6a-hydroxymaackiain HMM2 is involved primarily in the biosynthesis of (+)-pisatin Pisum sativum S-adenosyl-L-homocysteine + (+)-pisatin
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 ?

Synonyms

Synonyms Comment Organism
6a-HMK methyltransferase
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 Pisum sativum
HMM2
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 Pisum sativum

General Information

General Information Comment Organism
physiological function hairy roots containing RNAi constructs of HMM are deficient in (+)-pisatin biosynthesis, and accumulate 2,7,4'-trihydroxyisoflavanone, daidzein, isoformononetin, and liquiritigenin. Accumulation of compounds is consistent with the blockage of the synthesis of (+)-pisatin at the HI4'OMT catalyzed step resulting in the accumulation of liquiritigenin and 2,7,4'-trihydroxyisoflavanone and the diversion of the pathway to produce daidzein and isoformononetin Pisum sativum