Cloned (Comment) | Organism |
---|---|
- |
Pisum sativum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + (+)-6a-hydroxymaackiain | Pisum sativum | HMM2 is involved primarily in the biosynthesis of (+)-pisatin | S-adenosyl-L-homocysteine + (+)-pisatin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pisum sativum | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
root | - |
Pisum sativum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | in Pisum sativum, there are two highly similar hydroxymaackiain 3-O-methyltransferases HMM, with HMM1 prefering 2,7,4'-trihydroxyisoflavanone as a substrate and HMM2 being the specific O-methyltransferase that methylates (+)-6a-hydroxymaackiain | Pisum sativum | ? | - |
? | |
S-adenosyl-L-methionine + (+)-6a-hydroxymaackiain | isoform HMM2, 6a-hydroxymaackiain is the preferred substrate | Pisum sativum | S-adenosyl-L-homocysteine + (+)-pisatin | - |
? | |
S-adenosyl-L-methionine + (+)-6a-hydroxymaackiain | HMM2 is involved primarily in the biosynthesis of (+)-pisatin | Pisum sativum | S-adenosyl-L-homocysteine + (+)-pisatin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6a-HMK methyltransferase | - |
Pisum sativum |
HMM2 | - |
Pisum sativum |
General Information | Comment | Organism |
---|---|---|
physiological function | hairy roots containing RNAi constructs of HMM are deficient in (+)-pisatin biosynthesis, and accumulate 2,7,4'-trihydroxyisoflavanone, daidzein, isoformononetin, and liquiritigenin. Accumulation of compounds is consistent with the blockage of the synthesis of (+)-pisatin at the HI4'OMT catalyzed step resulting in the accumulation of liquiritigenin and 2,7,4'-trihydroxyisoflavanone and the diversion of the pathway to produce daidzein and isoformononetin | Pisum sativum |