BRENDA - Enzyme Database show
show all sequences of 2.1.1.267

Cation dependent O-methyltransferases from rice

Lee, Y.; Kim, B.; Chong, Y.; Lim, Y.; Ahn, J.; Planta 227, 641-647 (2008)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed in Escherichia coli as glutathione S-transferase fusion protein; expressed in Escherichia coli as glutathione S-transferase fusion protein; isoform ROMT-15, expression in Escherichia coli; isoform ROMT-17, expression in Escherichia coli
Oryza sativa
Engineering
Amino acid exchange
Commentary
Organism
D168L
isoform ROMT-15, complete loss of activity; mutation abolishes activity (with quercetin as substrate)
Oryza sativa
D194L
isoform ROMT-15, complete loss of activity; mutation abolishes activity (with quercetin as substrate)
Oryza sativa
D209L
isoform ROMT-17, complete loss of activity; mutation abolishes activity (with quercetin as substrate)
Oryza sativa
D234L
isoform ROMT-17, complete loss of activity; mutation abolishes activity (with quercetin as substrate)
Oryza sativa
E112L
isoform ROMT-17, 14% loss of activity; mutation results in 40% loss of activity (with quercetin as substrate)
Oryza sativa
E69L
isoform ROMT-15, 14% loss of activity; mutation results in 14% loss of activity (with quercetin as substrate)
Oryza sativa
N195I
isoform ROMT-15, complete loss of activity; mutation abolishes activity (with quercetin as substrate)
Oryza sativa
N235I
isoform ROMT-17, complete loss of activity; mutation abolishes activity (with quercetin as substrate)
Oryza sativa
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.036
-
tricetin
isoform ROMT-17
Oryza sativa
0.044
-
myricetin
isoform ROMT-17; pH 7.5, 37°C
Oryza sativa
0.072
-
caffeoyl-coenzyme A
isoform ROMT-17
Oryza sativa
0.072
-
tricetin
isoform ROMT-15
Oryza sativa
0.076
-
caffeoyl-coenzyme A
isoform ROMT-15
Oryza sativa
0.08
-
myricetin
isoform ROMT-15; pH 7.5, 37°C
Oryza sativa
0.09
-
luteolin
isoform ROMT-15
Oryza sativa
0.104
-
luteolin
isoform ROMT-17
Oryza sativa
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
isoform ROMT-15, poorly substitutes for Mg2+; isoform ROMT-17, poorly substitutes for Mg2+
Oryza sativa
Co2+
isoform ROMT-15, may substitute for Mg2+; isoform ROMT-17, may substitute for Mg2+; the enzyme is metal-dependent, Mg2+ is the best cation for catalytic activity, Co2+ shows 41% of the activity with Mg2+ (with quercetin as substrate); the enzyme is metal-dependent, Mg2+ is the best cation for catalytic activity, Co2+ shows 82% of the activity with Mg2+ (with quercetin as substrate)
Oryza sativa
Mg2+
isoform ROMT-15, required; isoform ROMT-17, required; the enzyme is metal-dependent, Mg2+ is the best cation for catalytic activity (with quercetin as substrate); the enzyme is metal-dependent, Mg2+ is the best cation for catalytic activity (with quercetin as substrate)
Oryza sativa
Mn2+
the enzyme is metal-dependent, Mg2+ is the best cation for catalytic activity, Mn2+ shows 69% of the activity with Mg2+ (with quercetin as substrate); the enzyme is metal-dependent, Mg2+ is the best cation for catalytic activity, Mn2+ shows 74% of the activity with Mg2+ (with quercetin as substrate)
Oryza sativa
Zn2+
isoform ROMT-15, poorly substitutes for Mg2+; isoform ROMT-17, poorly substitutes for Mg2+
Oryza sativa
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
27800
-
x * 27800, calculated, isoform ROMT-15
Oryza sativa
30600
-
x * 30600, SDS-PAGE, glutathione S-transferase fusion protein
Oryza sativa
31100
-
x * 31100, SDS-PAGE, glutathione S-transferase fusion protein
Oryza sativa
32000
-
x * 32000, calculated, isoform ROMT-17
Oryza sativa
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Oryza sativa
-
; isoform ROMT-15; isoform ROMT-17
-
Oryza sativa
Q9XGP7
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
additional information
isoform ROMT-15, expression in all tissues investigated
Oryza sativa
-
root
; isoform ROMT-15, highest expression in root and stem
Oryza sativa
-
stem
; expressed in stems only; isoform ROMT-15, highest expression in root and stem
Oryza sativa
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2 S-adenosyl-L-methionine + myricetin
the enzyme also catalyzes the methylation of luteolin, tricetin and caffeoyl-CoA. ROMT-15 exhibits similar kcat/Km values for the four substrates. ROMT-15 can not utilize naringenin, apigenin, or kaempferol. The 2,3-double bond and the O-dihydroxyl group are both required for catalytic activity
700855
Oryza sativa
2 S-adenosyl-L-homocysteine + syringetin
syringetin is the 3',5'-dimethyl ether of myricetin
-
-
?
2 S-adenosyl-L-methionine + myricetin
the enzyme also catalyzes the methylation of luteolin, tricetin and caffeoyl-CoA. ROMT-17 prefers tricetin. ROMT-15 can not utilize naringenin, apigenin, or kaempferol. The 2,3-double bond and the O-dihydroxyl group are both required for catalytic activity
700855
Oryza sativa
2 S-adenosyl-L-homocysteine + syringetin
syringetin is the 3',5'-dimethyl ether of myricetin
-
-
?
additional information
isoform ROMT-15, no substrate: naringenin, apigenin, kaempferol
700855
Oryza sativa
?
-
-
-
-
additional information
isoform ROMT-17, no substrate: naringenin, apigenin, kaempferol
700855
Oryza sativa
?
-
-
-
-
S-adenosyl-L-methionine + 7,8-dihydroxyflavone
-
700855
Oryza sativa
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-coenzyme A
isoform ROMT-15, 100% of the activity with myricetin
700855
Oryza sativa
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-coenzyme A
isoform ROMT-17, 100% of the activity with myricetin
700855
Oryza sativa
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + luteolin
isoform ROMT-15, 92% of the activity with myricetin
700855
Oryza sativa
S-adenosyl-L-homocysteine + ?
isoform ROMT-15, methylation at 3'-hydroxyl group
-
-
?
S-adenosyl-L-methionine + luteolin
isoform ROMT-17, 92% of the activity with myricetin
700855
Oryza sativa
S-adenosyl-L-homocysteine + ?
isoform ROMT-17, methylation at 3'-hydroxyl group
-
-
?
S-adenosyl-L-methionine + myricetin
-
700855
Oryza sativa
S-adenosyl-L-homocysteine + syringetin
isoform ROMT-15, methylation at 3'-hydroxyl group and at the 5' hydroxyl group
-
-
?
S-adenosyl-L-methionine + myricetin
-
700855
Oryza sativa
S-adenosyl-L-homocysteine + syringetin
isoform ROMT-17, methylation at 3'-hydroxyl group and at the 5' hydroxyl group
-
-
?
S-adenosyl-L-methionine + quercetin
-
700855
Oryza sativa
S-adenosyl-L-homocysteine + ?
isoform ROMT-15, methylation at 3'-hydroxyl group
-
-
?
S-adenosyl-L-methionine + quercetin
-
700855
Oryza sativa
S-adenosyl-L-homocysteine + ?
isoform ROMT-17, methylation at 3'-hydroxyl group
-
-
?
S-adenosyl-L-methionine + tricetin
isoform ROMT-15, methylation at 3'-hydroxyl group and at the 5' hydroxyl group. 87% of the activity with myricetin
700855
Oryza sativa
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + tricetin
isoform ROMT-17, methylation at 3'-hydroxyl group and at the 5' hydroxyl group. 87% of the activity with myricetin
700855
Oryza sativa
S-adenosyl-L-homocysteine + ?
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 27800, calculated, isoform ROMT-15; x * 30600, SDS-PAGE, glutathione S-transferase fusion protein; x * 31100, SDS-PAGE, glutathione S-transferase fusion protein; x * 32000, calculated, isoform ROMT-17
Oryza sativa
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at; assay at
Oryza sativa
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
-
assay at; assay at
Oryza sativa
Cofactor
Cofactor
Commentary
Organism
Structure
S-adenosyl-L-methionine
;
Oryza sativa
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli as glutathione S-transferase fusion protein
Oryza sativa
expressed in Escherichia coli as glutathione S-transferase fusion protein; isoform ROMT-15, expression in Escherichia coli; isoform ROMT-17, expression in Escherichia coli
Oryza sativa
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
S-adenosyl-L-methionine
-
Oryza sativa
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
D168L
isoform ROMT-15, complete loss of activity
Oryza sativa
D168L
mutation abolishes activity (with quercetin as substrate)
Oryza sativa
D194L
isoform ROMT-15, complete loss of activity
Oryza sativa
D194L
mutation abolishes activity (with quercetin as substrate)
Oryza sativa
D209L
isoform ROMT-17, complete loss of activity; mutation abolishes activity (with quercetin as substrate)
Oryza sativa
D234L
isoform ROMT-17, complete loss of activity; mutation abolishes activity (with quercetin as substrate)
Oryza sativa
E112L
isoform ROMT-17, 14% loss of activity; mutation results in 40% loss of activity (with quercetin as substrate)
Oryza sativa
E69L
isoform ROMT-15, 14% loss of activity
Oryza sativa
E69L
mutation results in 14% loss of activity (with quercetin as substrate)
Oryza sativa
N195I
isoform ROMT-15, complete loss of activity
Oryza sativa
N195I
mutation abolishes activity (with quercetin as substrate)
Oryza sativa
N235I
isoform ROMT-17, complete loss of activity; mutation abolishes activity (with quercetin as substrate)
Oryza sativa
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.036
-
tricetin
isoform ROMT-17
Oryza sativa
0.044
-
myricetin
isoform ROMT-17; pH 7.5, 37°C
Oryza sativa
0.072
-
caffeoyl-coenzyme A
isoform ROMT-17
Oryza sativa
0.072
-
tricetin
isoform ROMT-15
Oryza sativa
0.076
-
caffeoyl-coenzyme A
isoform ROMT-15
Oryza sativa
0.08
-
myricetin
isoform ROMT-15
Oryza sativa
0.08
-
myricetin
pH 7.5, 37°C
Oryza sativa
0.09
-
luteolin
isoform ROMT-15
Oryza sativa
0.104
-
luteolin
isoform ROMT-17
Oryza sativa
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
isoform ROMT-15, poorly substitutes for Mg2+; isoform ROMT-17, poorly substitutes for Mg2+
Oryza sativa
Co2+
isoform ROMT-15, may substitute for Mg2+; isoform ROMT-17, may substitute for Mg2+; the enzyme is metal-dependent, Mg2+ is the best cation for catalytic activity, Co2+ shows 41% of the activity with Mg2+ (with quercetin as substrate)
Oryza sativa
Co2+
the enzyme is metal-dependent, Mg2+ is the best cation for catalytic activity, Co2+ shows 82% of the activity with Mg2+ (with quercetin as substrate)
Oryza sativa
Mg2+
isoform ROMT-15, required; isoform ROMT-17, required; the enzyme is metal-dependent, Mg2+ is the best cation for catalytic activity (with quercetin as substrate)
Oryza sativa
Mg2+
the enzyme is metal-dependent, Mg2+ is the best cation for catalytic activity (with quercetin as substrate)
Oryza sativa
Mn2+
the enzyme is metal-dependent, Mg2+ is the best cation for catalytic activity, Mn2+ shows 69% of the activity with Mg2+ (with quercetin as substrate)
Oryza sativa
Mn2+
the enzyme is metal-dependent, Mg2+ is the best cation for catalytic activity, Mn2+ shows 74% of the activity with Mg2+ (with quercetin as substrate)
Oryza sativa
Zn2+
isoform ROMT-15, poorly substitutes for Mg2+; isoform ROMT-17, poorly substitutes for Mg2+
Oryza sativa
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
27800
-
x * 27800, calculated, isoform ROMT-15
Oryza sativa
30600
-
x * 30600, SDS-PAGE, glutathione S-transferase fusion protein
Oryza sativa
31100
-
x * 31100, SDS-PAGE, glutathione S-transferase fusion protein
Oryza sativa
32000
-
x * 32000, calculated, isoform ROMT-17
Oryza sativa
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
additional information
isoform ROMT-15, expression in all tissues investigated
Oryza sativa
-
root
isoform ROMT-15, highest expression in root and stem
Oryza sativa
-
root
-
Oryza sativa
-
stem
expressed in stems only; isoform ROMT-15, highest expression in root and stem
Oryza sativa
-
stem
-
Oryza sativa
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2 S-adenosyl-L-methionine + myricetin
the enzyme also catalyzes the methylation of luteolin, tricetin and caffeoyl-CoA. ROMT-15 exhibits similar kcat/Km values for the four substrates. ROMT-15 can not utilize naringenin, apigenin, or kaempferol. The 2,3-double bond and the O-dihydroxyl group are both required for catalytic activity
700855
Oryza sativa
2 S-adenosyl-L-homocysteine + syringetin
syringetin is the 3',5'-dimethyl ether of myricetin
-
-
?
2 S-adenosyl-L-methionine + myricetin
the enzyme also catalyzes the methylation of luteolin, tricetin and caffeoyl-CoA. ROMT-17 prefers tricetin. ROMT-15 can not utilize naringenin, apigenin, or kaempferol. The 2,3-double bond and the O-dihydroxyl group are both required for catalytic activity
700855
Oryza sativa
2 S-adenosyl-L-homocysteine + syringetin
syringetin is the 3',5'-dimethyl ether of myricetin
-
-
?
additional information
isoform ROMT-15, no substrate: naringenin, apigenin, kaempferol
700855
Oryza sativa
?
-
-
-
-
additional information
isoform ROMT-17, no substrate: naringenin, apigenin, kaempferol
700855
Oryza sativa
?
-
-
-
-
S-adenosyl-L-methionine + 7,8-dihydroxyflavone
-
700855
Oryza sativa
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-coenzyme A
isoform ROMT-15, 100% of the activity with myricetin
700855
Oryza sativa
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-coenzyme A
isoform ROMT-17, 100% of the activity with myricetin
700855
Oryza sativa
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + luteolin
isoform ROMT-15, 92% of the activity with myricetin
700855
Oryza sativa
S-adenosyl-L-homocysteine + ?
isoform ROMT-15, methylation at 3'-hydroxyl group
-
-
?
S-adenosyl-L-methionine + luteolin
isoform ROMT-17, 92% of the activity with myricetin
700855
Oryza sativa
S-adenosyl-L-homocysteine + ?
isoform ROMT-17, methylation at 3'-hydroxyl group
-
-
?
S-adenosyl-L-methionine + myricetin
-
700855
Oryza sativa
S-adenosyl-L-homocysteine + syringetin
isoform ROMT-15, methylation at 3'-hydroxyl group and at the 5' hydroxyl group
-
-
?
S-adenosyl-L-methionine + myricetin
-
700855
Oryza sativa
S-adenosyl-L-homocysteine + syringetin
isoform ROMT-17, methylation at 3'-hydroxyl group and at the 5' hydroxyl group
-
-
?
S-adenosyl-L-methionine + quercetin
-
700855
Oryza sativa
S-adenosyl-L-homocysteine + ?
isoform ROMT-15, methylation at 3'-hydroxyl group
-
-
?
S-adenosyl-L-methionine + quercetin
-
700855
Oryza sativa
S-adenosyl-L-homocysteine + ?
isoform ROMT-17, methylation at 3'-hydroxyl group
-
-
?
S-adenosyl-L-methionine + tricetin
isoform ROMT-15, methylation at 3'-hydroxyl group and at the 5' hydroxyl group. 87% of the activity with myricetin
700855
Oryza sativa
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + tricetin
isoform ROMT-17, methylation at 3'-hydroxyl group and at the 5' hydroxyl group. 87% of the activity with myricetin
700855
Oryza sativa
S-adenosyl-L-homocysteine + ?
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 27800, calculated, isoform ROMT-15; x * 30600, SDS-PAGE, glutathione S-transferase fusion protein; x * 32000, calculated, isoform ROMT-17
Oryza sativa
?
x * 31100, SDS-PAGE, glutathione S-transferase fusion protein
Oryza sativa
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Oryza sativa
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
-
assay at
Oryza sativa
Other publictions for EC 2.1.1.267
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737288
Azuma
-
MYB diplotypes at the color lo ...
Vitis vinifera
Tree Genet. Genomes
11
0000
2015
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-
1
-
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-
-
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1
-
1
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-
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2
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1
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-
-
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1
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1
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2
-
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1
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-
-
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-
-
-
-
-
-
-
-
-
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736999
Gomez Roldan
An O-methyltransferase modifie ...
Solanum lycopersicum
Plant J.
80
695-708
2014
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-
1
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1
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3
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1
1
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3
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6
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8
1
1
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3
1
1
-
1
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1
1
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1
-
-
-
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3
-
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1
1
-
-
-
-
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6
-
-
8
1
1
-
-
3
1
1
-
-
-
2
2
-
3
3
734429
Cho
-
Characterization of regiospeci ...
Solanum lycopersicum
J. Korean Soc. Appl. Biol. Chem.
55
749-755
2012
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1
-
-
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3
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1
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1
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5
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3
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1
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1
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5
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3
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3
3
721944
Fournier-Level
Genetic mechanisms underlying ...
Vitis vinifera
BMC Plant Biol.
11
179
2011
-
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1
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-
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-
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3
-
1
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2
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3
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1
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1
1
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3
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2
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3
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4
4
-
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720730
Hugueney
A novel cation-dependent O-met ...
Vitis vinifera
Plant Physiol.
150
2057-2070
2009
-
-
-
-
-
-
-
-
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4
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697062
Jeong
-
Flavonoids as substrates of Ba ...
Bacillus halodurans
Bull. Korean Chem. Soc.
29
1311-1314
2008
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700855
Lee
Cation dependent O-methyltrans ...
Oryza sativa
Planta
227
641-647
2008
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637316
Cacace
A flavonol O-methyltransferase ...
Catharanthus roseus
Phytochemistry
62
127-137
2003
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