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Literature summary for 2.1.1.250 extracted from

  • Ticak, T.; Kountz, D.J.; Girosky, K.E.; Krzycki, J.A.; Ferguson, D.J.
    A nonpyrrolysine member of the widely distributed trimethylamine methyltransferase family is a glycine betaine methyltransferase (2014), Proc. Natl. Acad. Sci. USA, 111, E4668-E4676.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.250

Cloned(Commentary)

Cloned (Comment) Organism
gene DSY3156 or mtgB Desulfitobacterium hafniense

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane transmembrane enzyme Desulfitobacterium hafniense 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Desulfitobacterium hafniense ability of the recombinant DSY3156 protein to methylate cob(I)alamin with various substrates. Quaternary amines such as carnitine and choline do not serve as substrates, nor do tertiary amines such as dimethylglycine or trimethylamine. Instead, DSY3156 protein carries out a robust methylation of cob(I)alamin in the presence of glycine betaine ?
-
 ?
additional information Desulfitobacterium hafniense Y51 ability of the recombinant DSY3156 protein to methylate cob(I)alamin with various substrates. Quaternary amines such as carnitine and choline do not serve as substrates, nor do tertiary amines such as dimethylglycine or trimethylamine. Instead, DSY3156 protein carries out a robust methylation of cob(I)alamin in the presence of glycine betaine ?
-
 ?

Organism

Organism UniProt Comment Textmining
Desulfitobacterium hafniense Q24MI2 gene DSY3156 or mtgB
-
Desulfitobacterium hafniense Y51 Q24MI2 gene DSY3156 or mtgB
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycine betaine + cob(I)alamin
-
 Desulfitobacterium hafniense dimethylglycine + methylcob(III)alamin
-
 ?
glycine betaine + cob(I)alamin
-
 Desulfitobacterium hafniense Y51 dimethylglycine + methylcob(III)alamin
-
 ?
additional information ability of the recombinant DSY3156 protein to methylate cob(I)alamin with various substrates. Quaternary amines such as carnitine and choline do not serve as substrates, nor do tertiary amines such as dimethylglycine or trimethylamine. Instead, DSY3156 protein carries out a robust methylation of cob(I)alamin in the presence of glycine betaine Desulfitobacterium hafniense ?
-
 ?
additional information ability of the recombinant DSY3156 protein to methylate cob(I)alamin with various substrates. Quaternary amines such as carnitine and choline do not serve as substrates, nor do tertiary amines such as dimethylglycine or trimethylamine. Instead, DSY3156 protein carries out a robust methylation of cob(I)alamin in the presence of glycine betaine Desulfitobacterium hafniense Y51 ?
-
 ?

Synonyms

Synonyms Comment Organism
DSY3156 protein
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 Desulfitobacterium hafniense
glycine betaine:cob(I)alamin methyltransferase
-
 Desulfitobacterium hafniense
MtgB
-
 Desulfitobacterium hafniense
MttB
-
 Desulfitobacterium hafniense
nonpyrrolysine MttB homolog
-
 Desulfitobacterium hafniense

Expression

Organism Comment Expression
Desulfitobacterium hafniense the enzyme is upregulated during growth on glycine betaine up

General Information

General Information Comment Organism
physiological function one of three non-Pyl MttBs in the organism is indeed a corrinoid-dependent methyltransferase, but with specificity for glycine betaine Desulfitobacterium hafniense