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Literature summary for 2.1.1.250 extracted from

  • Veit, K.; Ehlers, C.; Schmitz, R.
    Effects of nitrogen and carbon sources on transcription of soluble methyltransferases in Methanosarcina mazei strain Gö1 (2005), J. Bacteriol., 187, 6147-6154.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.250

Cloned(Commentary)

Cloned (Comment) Organism
gene mttB1C1, operon encoding TMA methylamine methyltransferase, quantitative RT-PCR expression analysis, comparison with other methylamine methyltransferases, overview. Transcriptional regulation of genes encoding methylamine methyltransferases (MT) in cells growing on TMA or methanol in the presence of ammonium, overview Methanosarcina mazei
gene mttB2C2, operon encoding TMA methylamine methyltransferase, quantitative RT-PCR expression analysis, comparison with other methylamine methyltransferases, overview. Transcriptional regulation of genes encoding methylamine methyltransferases (MT) in cells growing on TMA or methanol in the presence of ammonium, overview Methanosarcina mazei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein] Methanosarcina mazei
-
 a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine
-
 ?
trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein] Methanosarcina mazei Goe1
-
 a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine
-
 ?

Organism

Organism UniProt Comment Textmining
Methanosarcina mazei P58973 DSM 3647, gene mttB1C1
-
Methanosarcina mazei P58974 DSM 3647, gene mttB2C2
-
Methanosarcina mazei Goe1 P58973 DSM 3647, gene mttB1C1
-
Methanosarcina mazei Goe1 P58974 DSM 3647, gene mttB2C2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein]
-
 Methanosarcina mazei a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine
-
 ?
trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein]
-
 Methanosarcina mazei Goe1 a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine
-
 ?

Synonyms

Synonyms Comment Organism
MMA methyltransferase 1
-
 Methanosarcina mazei
MMA methyltransferase 2
-
 Methanosarcina mazei
mttB1C1
-
 Methanosarcina mazei
mttB2C2
-
 Methanosarcina mazei

Expression

Organism Comment Expression
Methanosarcina mazei transcription of the mtmB1C1 operon is not affected by the nitrogen source but appears to be increased when trimethylamine is the sole carbon and energy source. Transcription of the homologous mtmB1C1 operon occurs at a constant level independently of the nitrogen source up
Methanosarcina mazei under nitrogen limitation, a 543fold up-regulation of the mtmB2C2 operon, encoding MMA methyltransferase 2, is obtained when methanol is used as carbon source up

General Information

General Information Comment Organism
metabolism when growing on trimethylamine, nitrogen fixation does not occur in the cells, indicating that ammonium released during trimethylamine degradation is sufficient to serve as a nitrogen source and represses nif gene induction, transcriptional regulation of soluble methyltransferases, which catalyze the initial step of methylamine consumption by methanogenesis, in response to different carbon and nitrogen sources, overview. Transcription of the operon encoding TMA methyltransferase is not regulated in response to the nitrogen source. Regulation of soluble methyltransferases in response to different nitrogen and carbon sources, overview Methanosarcina mazei