Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.249 extracted from

  • Paul, L.; Ferguson Jr., D.; Krzycki, J.
    The trimethylamine methyltransferase gene and multiple dimethylamine methyltransferase genes of Methanosarcina barkeri contain in-frame and read-through amber codons (2000), J. Bacteriol., 182, 2520-2529.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.249

Cloned(Commentary)

Cloned (Comment) Organism
gene mtbB2, DNA and amino acid sequence determination and analysis, homology sequence comparison, co-transcription with of gene mttB encoding the TMA methyltransferase. The genes, organized on the chromosome in the order mtbC, mttB, mttC, mttP, and mtbB1, form a single transcriptional unit. The genes encoding the three types of methyltransferases that initiate methanogenesis from methylamine contain in-frame amber codons that are suppressed during expression of the characterized methyltransferases Methanosarcina barkeri
gene mtbB3, DNA and amino acid sequence determination and analysis, homology sequence comparison, co-transcription with of gene mttB encoding the TMA methyltransferase. The genes, organized on the chromosome in the order mtbC, mttB, mttC, mttP, and mtbB1, form a single transcriptional unit. The genes encoding the three types of methyltransferases that initiate methanogenesis from methylamine contain in-frame amber codons that are suppressed during expression of the characterized methyltransferases Methanosarcina barkeri
genes mtbB1, mtbB2, and mtbB3, DNA and amino acid sequence determination and analysis, homology sequence comparison, co-transcription with of gene mttB encoding the TMA methyltransferase. The genes, organized on the chromosome in the order mtbC, mttB, mttC, mttP, and mtbB1, form a single transcriptional unit. The genes encoding the three types of methyltransferases that initiate methanogenesis from methylamine contain in-frame amber codons that are suppressed during expression of the characterized methyltransferases Methanosarcina barkeri

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 x * 50000, SDS-PAGE Methanosarcina barkeri

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dimethylamine + a [Co(I) dimethylamine-specific corrinoid protein] Methanosarcina barkeri
-
 a [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine
-
 ?

Organism

Organism UniProt Comment Textmining
Methanosarcina barkeri O93661 MtbB1; genes mtbB1, mtbB2, or mtbB3
-
Methanosarcina barkeri Q9P9M9 MtbB3; gene mtbB3
-
Methanosarcina barkeri Q9P9N0 mtbB2; gene mtbB2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dimethylamine + a [Co(I) dimethylamine-specific corrinoid protein]
-
 Methanosarcina barkeri a [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine
-
 ?
dimethylamine + a [Co(I) dimethylamine-specific corrinoid protein] the DMA methyltransferase cognate corrinoid protein MtbC Methanosarcina barkeri a [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine
-
 ?

Subunits

Subunits Comment Organism
? x * 50000, SDS-PAGE Methanosarcina barkeri

Synonyms

Synonyms Comment Organism
dimethylamine methyltransferase
-
 Methanosarcina barkeri
DMA methyltransferase
-
 Methanosarcina barkeri
MtbB
-
 Methanosarcina barkeri
MtbB2
-
 Methanosarcina barkeri
MtbB3
-
 Methanosarcina barkeri

General Information

General Information Comment Organism
metabolism three different methyltransferases initiate methanogenesis from trimethylamine, dimethylamine, or monomethylamine by methylating different cognate corrinoid proteins that are subsequently used to methylate coenzyme M Methanosarcina barkeri