Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.246 extracted from

  • Pritchett, M.A.; Metcalf, W.W.
    Genetic, physiological and biochemical characterization of multiple methanol methyltransferase isozymes in Methanosarcina acetivorans C2A (2005), Mol. Microbiol., 56, 1183-1194.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Methanosarcina acetivorans methyltransferase 2, MT2, transfers the methyl group from the methylated corrinoid protein to coenzyme M, i.e. 2-mercaptoethanesulfonic acid. Methyl-coenzyme M is then disproportionated, with one molecule being oxidized to CO2 to provide the six electrons required for reduction of three additional methyl-coenzyme M molecules to methane ?
-
?

Organism

Organism UniProt Comment Textmining
Methanosarcina acetivorans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information methyltransferase 2, MT2, transfers the methyl group from the methylated corrinoid protein to coenzyme M, i.e. 2-mercaptoethanesulfonic acid. Methyl-coenzyme M is then disproportionated, with one molecule being oxidized to CO2 to provide the six electrons required for reduction of three additional methyl-coenzyme M molecules to methane Methanosarcina acetivorans ?
-
?

Synonyms

Synonyms Comment Organism
Co-methyl-5-hydroxybenzimidazolylcobamide:2-mercapto-ethanesulphonic acid methyltransferase
-
Methanosarcina acetivorans
mtaA
-
Methanosarcina acetivorans

General Information

General Information Comment Organism
evolution specific MT1/corrinoid pairs have been identified for methanol (MtaC, MtaB), trimethylamine (MttC, MttB), dimethylamine (MtbC, MtbB), methylamine (MtmC, MtmB) and methylsulfide (MtsA, MtsB). MT2 proteins are somewhat less specific with MtaA being used for methanol, and poorly for trimethylamine showing 5% of the methanol-dependent activity, and an enzyme designated MtbA, EC 2.1.1.1247, being used for all three methylamines. The MtsA protein apparently catalyses both MT1 and MT2 reactions in the activation of dimethylsulfide Methanosarcina acetivorans
metabolism methanol catabolism in Methanosarcina species requires the concerted effort of methanol:5-hydroxybenzimidazolylcobamide methyltransferase, MtaB, a corrinoid-containing methyl-accepting protein, MtaC, and Co-methyl-5-hydroxybenzimidazolylcobamide:2-mercapto-ethanesulfonic acid methyltransferase, MtaA Methanosarcina acetivorans