Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
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additional information | Methanosarcina acetivorans | methyltransferase 2, MT2, transfers the methyl group from the methylated corrinoid protein to coenzyme M, i.e. 2-mercaptoethanesulfonic acid. Methyl-coenzyme M is then disproportionated, with one molecule being oxidized to CO2 to provide the six electrons required for reduction of three additional methyl-coenzyme M molecules to methane | ? | - |
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Organism | UniProt | Comment | Textmining |
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Methanosarcina acetivorans | - |
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Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | methyltransferase 2, MT2, transfers the methyl group from the methylated corrinoid protein to coenzyme M, i.e. 2-mercaptoethanesulfonic acid. Methyl-coenzyme M is then disproportionated, with one molecule being oxidized to CO2 to provide the six electrons required for reduction of three additional methyl-coenzyme M molecules to methane | Methanosarcina acetivorans | ? | - |
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Synonyms | Comment | Organism |
---|---|---|
Co-methyl-5-hydroxybenzimidazolylcobamide:2-mercapto-ethanesulphonic acid methyltransferase | - |
Methanosarcina acetivorans |
mtaA | - |
Methanosarcina acetivorans |
General Information | Comment | Organism |
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evolution | specific MT1/corrinoid pairs have been identified for methanol (MtaC, MtaB), trimethylamine (MttC, MttB), dimethylamine (MtbC, MtbB), methylamine (MtmC, MtmB) and methylsulfide (MtsA, MtsB). MT2 proteins are somewhat less specific with MtaA being used for methanol, and poorly for trimethylamine showing 5% of the methanol-dependent activity, and an enzyme designated MtbA, EC 2.1.1.1247, being used for all three methylamines. The MtsA protein apparently catalyses both MT1 and MT2 reactions in the activation of dimethylsulfide | Methanosarcina acetivorans |
metabolism | methanol catabolism in Methanosarcina species requires the concerted effort of methanol:5-hydroxybenzimidazolylcobamide methyltransferase, MtaB, a corrinoid-containing methyl-accepting protein, MtaC, and Co-methyl-5-hydroxybenzimidazolylcobamide:2-mercapto-ethanesulfonic acid methyltransferase, MtaA | Methanosarcina acetivorans |