Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | dependent on, kinetics, overview | Methanosarcina barkeri |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Methanosarcina barkeri | transferase MtaA catalyzes the transfer of the methyl group from methylated transferase MtaBC to coenzyme M. Instead of methylated transferase MtaBC, MtaA can also use free methylcobalamin as the methyl donor. MtaA activates coenzyme M for nucleophilic attack of the methyl group of the methylcobamide | ? | - |
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Organism | UniProt | Comment | Textmining |
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Methanosarcina barkeri | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | transferase MtaA catalyzes the transfer of the methyl group from methylated transferase MtaBC to coenzyme M. Instead of methylated transferase MtaBC, MtaA can also use free methylcobalamin as the methyl donor. MtaA activates coenzyme M for nucleophilic attack of the methyl group of the methylcobamide | Methanosarcina barkeri | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
methanol:cob(I)alamin methyltransferase | - |
Methanosarcina barkeri |
mtaA | - |
Methanosarcina barkeri |
General Information | Comment | Organism |
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metabolism | the enzyme system from Methanosarcina barkeri is composed of two methyltransferases, transferase MT1, which is composed of a 50-kDa subunit, MtaB, and a 27-kDa corrinoid-harbouring subunit, MtaC, catalyzes the methylation of free cob(1)alamin with methanol, EC 2.1.1.90, and transferase MT2 catalyzes the transfer of the methyl group from CH,-MT1 to coenzyme M. Instead of CH,-MTI, MtaA can also use free methylcobalamin as the methyl donor. MtaC with its supernucleophilic cobamide prosthetic group accepts the methyl group from methanol and passes it to coenzyme M, MtaB activates methanol for nucleophilic attack by the cob(1)amide, and MtaA activates coenzyme M for nucleophilic attack of the methyl group of the methylcobamide | Methanosarcina barkeri |