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Literature summary for 2.1.1.233 extracted from

  • Hwang, J.; Lee, J.A.; Pallas, D.C.
    Leucine carboxyl methyltransferase 1 (LCMT-1) methylates protein phosphatase 4 (PP4) and protein phosphatase 6 (PP6) and differentially regulates the stable formation of different PP4 holoenzymes (2016), J. Biol. Chem., 291, 21008-21019 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine Mus musculus LCMT-1 is the major methyltransferase in embryonic fibroblasts for all three PP2A subfamily phosphatases, PP2Ac, PP4c, and PP6c S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
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 ?
S-adenosyl-L-methionine + [protein phosphatase 4 catalytic subunit]-leucine Mus musculus LCMT-1 is the major methyltransferase in embryonic fibroblasts for all three PP2A subfamily phosphatases, PP2Ac, PP4c, and PP6c S-adenosyl-L-homocysteine + [protein phosphatase 4 catalytic subunit]-leucine methyl ester
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 ?
S-adenosyl-L-methionine + [protein phosphatase 6 catalytic subunit]-leucine Mus musculus LCMT-1 is the major methyltransferase in embryonic fibroblasts for all three PP2A subfamily phosphatases, PP2Ac, PP4c, and PP6c S-adenosyl-L-homocysteine + [protein phosphatase 6 catalytic subunit]-leucine methyl ester
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus A2RTH5
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Source Tissue

Source Tissue Comment Organism Textmining
fibroblast embryonic Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine
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 Mus musculus S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
-
 ?
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine LCMT-1 is the major methyltransferase in embryonic fibroblasts for all three PP2A subfamily phosphatases, PP2Ac, PP4c, and PP6c Mus musculus S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
-
 ?
S-adenosyl-L-methionine + [protein phosphatase 4 catalytic subunit]-leucine
-
 Mus musculus S-adenosyl-L-homocysteine + [protein phosphatase 4 catalytic subunit]-leucine methyl ester
-
 ?
S-adenosyl-L-methionine + [protein phosphatase 4 catalytic subunit]-leucine LCMT-1 is the major methyltransferase in embryonic fibroblasts for all three PP2A subfamily phosphatases, PP2Ac, PP4c, and PP6c Mus musculus S-adenosyl-L-homocysteine + [protein phosphatase 4 catalytic subunit]-leucine methyl ester
-
 ?
S-adenosyl-L-methionine + [protein phosphatase 6 catalytic subunit]-leucine
-
 Mus musculus S-adenosyl-L-homocysteine + [protein phosphatase 6 catalytic subunit]-leucine methyl ester
-
 ?
S-adenosyl-L-methionine + [protein phosphatase 6 catalytic subunit]-leucine LCMT-1 is the major methyltransferase in embryonic fibroblasts for all three PP2A subfamily phosphatases, PP2Ac, PP4c, and PP6c Mus musculus S-adenosyl-L-homocysteine + [protein phosphatase 6 catalytic subunit]-leucine methyl ester
-
 ?

General Information

General Information Comment Organism
malfunction mouse embryonic fibroblasts derived from LCMT-1 knock-out mouse embryos have reduced levels of PP2A B regulatory subunit and PP4R1 relative to control mouse embryonic fibroblasts, indicating that LCMT-1 is important for maintaining normal levels of these subunits. LCMT-1 homozygous knock-out mouse embryonic fibroblasts exhibit hyperphosphorylation of HDAC3, a reported target of the methylation-dependent PP4R1-PP4c complex Mus musculus
physiological function the enzyme coordinately regulates the carboxyl methylation of PP2A-related phosphatases and, consequently, their holoenzyme assembly and function Mus musculus