Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-synuclein | alpha-syn, negatively regulates protein phosphatase 2A (PP2A) methylation via LCMT-1 and PME-1, whilst activation of LCMT-1 and inhibition of PME-1 reverses this process | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine | Mus musculus | - |
S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester | - |
? | |
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine | Mus musculus C57BL/6N | - |
S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | A0A0U1RNF2 | - |
- |
Mus musculus C57BL/6N | A0A0U1RNF2 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | - |
Mus musculus | - |
neuron | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine | - |
Mus musculus | S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester | - |
? | |
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine | - |
Mus musculus C57BL/6N | S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LCMT-1 | - |
Mus musculus |
leucine carboxyl methyltransferase | - |
Mus musculus |
PME-1 | - |
Mus musculus |
PP2A methyltransferase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | alpha-syn overexpression results in PP2A demethylation. This demethylation is mediated via downregulated leucine carboxyl methyltransferase (LCMT-1) expression | down |
General Information | Comment | Organism |
---|---|---|
malfunction | alpha-synuclein (alpha-syn) overexpression induces increased alpha-syn phosphorylation at Ser129, and protein phosphatase 2A (PP2A) inhibition, in vitro and in vivo. alpha-Syn overexpression results in PP2A demethylation. This demethylation is mediated via downregulated leucine carboxyl methyltransferase (LCMT-1) expression, and upregulated protein phosphatase methylesterase (PME-1, EC 3.1.1.89) expression. Furthermore, LCMT-1 overexpression, or PME-1 inhibition, reverses alpha-syn-induced increases in alpha-syn phosphorylation and apoptosis | Mus musculus |
physiological function | LCMT-1 overexpression or protein phosphatase methylesterase (PME-1, EC 3.1.1.89) inhibition protects against alpha-syn-induced protein phosphatase 2A (PP2A) inhibition, and increases in apoptosis of SK-N-SH cells | Mus musculus |