Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
38000 | - |
x * 38000, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Subunits | Comment | Organism |
---|---|---|
? | x * 38000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
LCMT1 | - |
Homo sapiens |
leucine carboxyl methyltransferase-1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | depletion of leucine carboxyl methyltransferase-1, LCMT1, or overexpression of protein phosphatase methylesterase-1, PME-1, lead to long spindles. In contrast, depletion of PME-1, pharmacological inhibition of PME-1 or overexpression of LCMT1 lead to short spindles. Perturbation of the LCMT1-PME-1 methylation equilibrium leads to mitotic arrest, spindle assembly checkpoint activation, defective cell divisions, induction of apoptosis and reduced cell viability, phenotype, overview | Homo sapiens |
physiological function | leucine carboxyl methyltransferase-1, LCMT1, and protein phosphatase methylesterase-1, PME-1, are essential enzymes that regulate the methylation of the protein phosphatase 2A catalytic subunit. The two enzymes have been linked to the regulation of cell growth and proliferation, and a role of LCMT1-PME-1 methylation equilibrium in controlling mitotic spindle size. The LCMT1-PME-1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division | Homo sapiens |